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8-iso-13,14-dihydro-15-keto Prostaglandin F2α

Catalog No. T36165 CAS 191919-02-5

Synonyms: 8-iso-13,14-dihydro-15-keto Prostaglandin F2α

8-iso-13,14-dihydro-15-keto Prostaglandin F2α (8-iso-13,14-dihydro-15-keto PGF2α) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF2α), in rabbits, monkeys and humans. 8-iso PGF2α is a PG-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-isoprostane is infused into rabbits. Early in the infusion (within 10 minutes) 8-iso-13,14-dihydro-15-keto PGF2α was a significant component of the metabolite profile, which was comprised mostly of dinor 8-isoprostane metabolites. 8-iso-13,14-dihydro-15-keto PGF2α weakly inhibits the U-46619 or collagen-induced aggregation of human platelets, although a number of the E-series isoprostanes are much more potent in this assay.

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8-iso-13,14-dihydro-15-keto Prostaglandin F2α Chemical Structure

8-iso-13,14-dihydro-15-keto Prostaglandin F2α, CAS 191919-02-5

Pack Size	Availability	Price/USD
100 μg	35 days	$ 294.00
500 μg	35 days	$ 1,380.00
1 mg	35 days	$ 2,560.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	8-iso-13,14-dihydro-15-keto Prostaglandin F2α
Molecular Weight	354.48
Formula	C20H34O5
CAS No.	191919-02-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

PBS (pH 7.2): >10 mg/mL (from PGF2a)

10 mM Na2CO3: >6.5 mg/mL (from PGF2a)

Ethanol: >100 mg/mL (from PGF2a)

DMSO: >100 mg/mL (from PGF2a)

DMF: >100 mg/mL (from PGF2a)

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Keywords

8-iso-13,14-dihydro-15-keto Prostaglandin F2α 191919-02-5 8 iso 13,14 dihydro 15 keto Prostaglandin F2α 8-iso-13,14-dihydro-15-keto Prostaglandin F-2α 8-iso-13,14-dihydro-15-keto Prostaglandin F2alpha 8iso13,14dihydro15keto Prostaglandin F2α 8-iso-13,14-dihydro-15-keto Prostaglandin F2a inhibitor inhibit

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