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6-(γ,γ-Dimethylallylamino)purine

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Catalog No. T5581Cas No. 2365-40-4
Alias Triacanthine, N6-(2-lsopentenyl)adenine

6-(γ,γ-Dimethylallylamino)purine (Triacanthine), which is a plant growth substance, shows hypertensive and antitumor activity, also cardiotonic, antispasmodic and a respiratory analeptic.

6-(γ,γ-Dimethylallylamino)purine

6-(γ,γ-Dimethylallylamino)purine

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🥰Excellent
Purity: 99.89%
Catalog No. T5581Alias Triacanthine, N6-(2-lsopentenyl)adenineCas No. 2365-40-4
6-(γ,γ-Dimethylallylamino)purine (Triacanthine), which is a plant growth substance, shows hypertensive and antitumor activity, also cardiotonic, antispasmodic and a respiratory analeptic.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mg$31In StockIn Stock
100 mg$41In StockIn Stock
500 mg$67In StockIn Stock
1 g$95In StockIn Stock
1 mL x 10 mM (in DMSO)$45In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.89%
Color:White
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Product Introduction

Bioactivity
Description
6-(γ,γ-Dimethylallylamino)purine (Triacanthine), which is a plant growth substance, shows hypertensive and antitumor activity, also cardiotonic, antispasmodic and a respiratory analeptic.
In vitro
6-(γ,γ-Dimethylallylamino)purinee significantly inhibited EJ cell proliferation (IC50 600μM). Flow cytometry analysis revealed that cells were arrested in the G1 phase, and apoptotic cells accumulated in the sub-G1 phase in a dose-dependent manner. 6-(γ,γ-Dimethylallylamino)purinee inhibited the G1-S transition by deterring complex formation between cyclin-dependent kinases and cyclins, thereby up-regulating cell cycle inhibitors p21WAF1 and p27KIP1.
In vivo
In an in vivo study, 6-(γ,γ-Dimethylallylamino)purinee significantly limited growth of xenografted tumors. Interestingly, while cisplatin resulted in significant weight loss after a 5-mg/kg dose, 6-(γ,γ-Dimethylallylamino)purinee did not cause weight loss, behavioral abnormalities, altered biochemical parameters, or tissue staining. A single oral dose acute-toxicity test (6-(γ,γ-Dimethylallylamino)purinee 2,000mg/kg) produced no adverse cytotoxic effects via blood biochemical tests and tissue-organ staining.
SynonymsTriacanthine, N6-(2-lsopentenyl)adenine
Chemical Properties
Molecular Weight203.24
FormulaC10H13N5
Cas No.2365-40-4
SmilesCC(C)=CCNc1ncnc2[nH]cnc12
Relative Density.1.28 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 32.33 mg/mL (159.07 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4.92 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.9203 mL24.6015 mL49.2029 mL246.0146 mL
5 mM0.9841 mL4.9203 mL9.8406 mL49.2029 mL
10 mM0.4920 mL2.4601 mL4.9203 mL24.6015 mL
20 mM0.2460 mL1.2301 mL2.4601 mL12.3007 mL
50 mM0.0984 mL0.4920 mL0.9841 mL4.9203 mL
100 mM0.0492 mL0.2460 mL0.4920 mL2.4601 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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