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2-Methylthioadenosine diphosphate trisodium

Catalog No. T23581 CAS 475193-31-8

Synonyms: 2 Methylthio ADP, 2MeSADP, 2-Methylthio-ADP, 2 MeS ADP, 2-MeS-ADP

2-MeS-ADP is a purinergic agonist that acts by displaying selectivity for P2Y1, P2Y12, and P2Y13 receptors and inhibiting cAMP accumulation.

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2-Methylthioadenosine diphosphate trisodium Chemical Structure

2-Methylthioadenosine diphosphate trisodium, CAS 475193-31-8

Pack Size	Availability	Price/USD
1 mg	35 days	$ 143.00
5 mg	35 days	$ 633.00
10 mg	35 days	$ 973.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

2-MeS-ADP is a purinergic agonist that acts by displaying selectivity for P2Y1, P2Y12, and P2Y13 receptors and inhibiting cAMP accumulation.

Synonyms	2 Methylthio ADP, 2MeSADP, 2-Methylthio-ADP, 2 MeS ADP, 2-MeS-ADP
Molecular Weight	542.26
Formula	C11H17N5Na3O10P2S
CAS No.	475193-31-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Gao ZG, Jacobson KA. Distinct Signaling Patterns of Allosteric Antagonism at the P2Y(1) Receptor. Mol Pharmacol. 2017 Nov;92(5):613-626. doi: 10.1124/mol.117.109660. Epub 2017 Sep 1. PubMed PMID: 28864555; PubMed Central PMCID: PMC5635520. 2. Muscella A, Cossa LG, Vetrugno C, Antonaci G, Marsigliante S. Inhibition of ZL55 cell proliferation by ADP via PKC-dependent signalling pathway. J Cell Physiol. 2018 Mar;233(3):2526-2536. doi: 10.1002/jcp.26128. Epub 2017 Sep 4. PubMed PMID: 28777435. 3. Guarracino JF, Cinalli AR, Fernández V, Roquel LI, Losavio AS. P2Y13 receptors mediate presynaptic inhibition of acetylcholine release induced by adenine nucleotides at the mouse neuromuscular junction. Neuroscience. 2016 Jun 21;326:31-44. doi: 10.1016/j.neuroscience.2016.03.066. Epub 2016 Apr 4. PubMed PMID: 27058149. 4. Förster D, Reiser G. Nucleotides protect rat brain astrocytes against hydrogen peroxide toxicity and induce antioxidant defense via P2Y receptors. Neurochem Int. 2016 Mar;94:57-66. doi: 10.1016/j.neuint.2016.02.006. Epub 2016 Feb 17. PubMed PMID: 26898403.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

2-Methylthioadenosine diphosphate trisodium 475193-31-8 2 Methylthio ADP 2MeSADP 2-Methylthio-ADP 2 Methylthioadenosine diphosphate trisodium 2-Methylthioadenosine 2 MeS ADP 2-MeS-ADP 2Methylthioadenosine diphosphate trisodium inhibitor inhibit

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