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(-)-Epigallocatechin-3-(3''-O-methyl) gallate

Name: (-)-Epigallocatechin-3-(3''-O-methyl) gallate
Brand: TargetMol
SKU: TN1608
Price: 159 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: (-)-EGCG-3''-O-ME) Copy Product Info

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Synonyms: (-)-EGCG-3''-O-ME

Catalog No. TN1608 Copy Product Info

Purity: 99.59%

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(-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3’'-O-ME) is a natural compound isolated from tea leaves. (-)-EGCG-3’'-O-ME exhibits potent antioxidant, anti-inflammatory, and antibacterial activities, and enhances the bond stability between etching-rinsing agents and dentin. (-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3’'-O-ME) can be used in tumor and metabolic syndrome research.

Cas No. 83104-87-4

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$159	-	In Stock
5 mg	$392	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.59%

Appearance:Solid

Color:Red

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	(-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3’'-O-ME) is a natural compound isolated from tea leaves. (-)-EGCG-3’'-O-ME exhibits potent antioxidant, anti-inflammatory, and antibacterial activities, and enhances the bond stability between etching-rinsing agents and dentin. (-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3’'-O-ME) can be used in tumor and metabolic syndrome research.
Targets & IC50	DPPH-derived radicals:36.54 μM, α-amylase:0.54 mg/mL, COX-2:0.17 ± 0.03 μM, ABTS radicals:2.59 μM
In vitro	Methods: Mouse RAW264.73 macrophages were pretreated with (-)-epigallocatechin-3-(3''-O-methyl) gallate (0–12.5 μM) for 30 minutes, then stimulated with SNP (0.25 mM) for 30 minutes. ROS levels were measured by flow cytometry (DHR123 fluorescence). Results: (-)-Epigallocatechin-3-(3''-O-methyl) gallate significantly reduced SNP-induced ROS levels. [1] Methods: HaCaT cells were treated with (-)-epigallocatechin-3-(3''-O-methyl) gallate (0–12.5 μM) for 24, 48, and 72 h, and cell proliferation was assessed using the MTT assay. Results: (-)-Epigallocatechin-3-(3''-O-methyl) gallate significantly promoted cell proliferation starting at 24 h. [1]
Synonyms	(-)-EGCG-3''-O-ME

Chemical Properties

Molecular Weight	472.4
Formula	C₂₃H₂₀O₁₁
Cas No.	83104-87-4
Smiles	O(C(=O)C1=CC(OC)=C(O)C(O)=C1)[C@H]2[C@H](OC=3C(C2)=C(O)C=C(O)C3)C4=CC(O)=C(O)C(O)=C4
Relative Density.	1.77 g/cm3

Storage & Solubility Information

Storage

Store at low temperature,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

Immunology & Inflammation relatedEpigallocatechin-3-(3''-O-methyl) gallateEGCG-3''-O-MEBacterialAntioxidant

Related Tags: (-)-Epigallocatechin-3-(3''-O-methyl) gallate chemical structure | (-)-Epigallocatechin-3-(3''-O-methyl) gallate in vitro | (-)-Epigallocatechin-3-(3''-O-methyl) gallate formula | (-)-Epigallocatechin-3-(3''-O-methyl) gallate molecular weight