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TargetMol | Compound Library

Sodium Channel Blocker Library

Catalog No. L7400

Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. According to the trigger that opens the channel for such ions, they can be classified into Voltage-gated sodium channels and ligand-gated sodium channels. Sodium channels are highly selective for the transport of sodium ions across cell membranes. In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Many of the most common neurological disorders, such as epilepsy, migraine, neurodegenerative diseases, and neuropathic pain, involve abnormalities of neuronal excitability. There is a growing body of data that implicates abnormal expression and function of voltage-gated sodium channels (VGSCs) in these disorders. Pharmacological inhibitors of VGSCs have been used for decades to treat epileptic seizures, the most common disease of neuronal excitability, and arrhythmia, and it is becoming increasingly evident that these antiepileptic VGSC blockers might also be efficacious against a broad range of neurological disorders. Sodium channels serve as specific target for a large variety of chemically distinct neurotoxins produced by many different animals and plants. The development of drugs with enhanced selectivity for specific VGSC isoforms might be an effective and novel approach for the treatment of several neurological diseases. TargetMol’s Sodium Channel Blocker Library collects 118 reported sodium channel blockers and agonists, and is an ideal tool for screening more selective and efficient drugs targeting potassium channels.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L7400

Sodium Channel Blocker Library
sizeIn stock
  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 118 sodium channel blockers and agonists for high throughput and high content screening;
  • Targeting different subtypes of sodium channels, such as Nav1.1, Nav1.2, Nav1.3, Nav1.4, etc.
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, some of which are FDA approved;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

Sodium Channel
Potassium Channel
Calcium Channel
Autophagy
AChR
Parasite
Na+/Ca2+ Exchanger
Apoptosis
ATPase
GABA Receptor
Histamine Receptor
NF-κB
5-HT Receptor
Carbonic Anhydrase
Adrenergic Receptor
Dopamine Receptor
Antifungal
Mitophagy
Virus Protease
MRP
ERK
iGluR
NMDAR
GluR
Norepinephrine
Antibacterial
EGFR
MEK
HIV Protease
Chloride channel
HBV
Wnt/beta-catenin
Serotonin Transporter
Serine/threonin kinase
Caspase
TRP/TRPV Channel
PDE
Gamma-secretase
Drug Metabolite
P2X Receptor
Monoamine Transporter
CaMK
COX
TGF-beta/Smad
DNA/RNA Synthesis
Beta-Secretase
P-gp
SARS-CoV
Trk receptor
IκB/IKK
Beta Amyloid
Endogenous Metabolite
HDAC
P450
DNA Methyltransferase
Sigma receptor
Antibiotic
AhR
HER

Keywords