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CD3 epsilon/CD3e Protein, Human, Recombinant (hFc & Avi), Biotinylated

Catalog No. TMPJ-00089
Synonyms: T-Cell Surface Antigen T3/Leu-4 ε Chain, T3E, T-Cell Surface Glycoprotein CD3 Epsilon Chain, T-Cell Surface Glycoprotein CD3 ε Chain, T-Cell Surface Antigen T3/Leu-4 Epsilon Chain, CD3E

T-Cell Surface Glycoprotein CD3 ε Chain (CD3ε) is a single-pass type I membrane protein. CD3ε contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex (TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CD3 epsilon/CD3e Protein, Human, Recombinant (hFc & Avi), Biotinylated
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 355.00
100 μg 5 days $ 963.00
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Biological Description
Technical Params
Product Properties
Description T-Cell Surface Glycoprotein CD3 ε Chain (CD3ε) is a single-pass type I membrane protein. CD3ε contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex (TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
Species Human
Expression System HEK293 Cells
Tag C-hFc-Avi
Accession Number P07766
Synonyms T-Cell Surface Antigen T3/Leu-4 ε Chain, T3E, T-Cell Surface Glycoprotein CD3 Epsilon Chain, T-Cell Surface Glycoprotein CD3 ε Chain, T-Cell Surface Antigen T3/Leu-4 Epsilon Chain, CD3E
Amino Acid Asp23-Asp126
Construction Asp23-Asp126
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 45-60 KDa (reducing condition)
Endotoxin < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background T-Cell Surface Glycoprotein CD3 ε Chain (CD3ε) is a single-pass type I membrane protein. CD3ε contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex (TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.

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Keywords

CD3 epsilon/CD3e Protein, Human, Recombinant (hFc & Avi), Biotinylated T-Cell Surface Antigen T3/Leu-4 ε Chain T3E T-Cell Surface Glycoprotein CD3 Epsilon Chain T-Cell Surface Glycoprotein CD3 ε Chain T-Cell Surface Antigen T3/Leu-4 Epsilon Chain CD3E recombinant recombinant-proteins proteins protein

 

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