Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Metallo-β-lactamase-IN-7 is a potent inhibitor of VIM -Type metallo-β-lactamase with IC 50 s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5, respectively. Metallo-β-lactamase-IN-7 also enhances the antibacterial activity of Meropenem against the Gram-negative bacterial strains [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Metallo-β-lactamase-IN-7 is a potent inhibitor of VIM -Type metallo-β-lactamase with IC 50 s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5, respectively. Metallo-β-lactamase-IN-7 also enhances the antibacterial activity of Meropenem against the Gram-negative bacterial strains [1]. |
In vitro | Metallo-β-lactamase-IN-7 (compound 59) at a concentration of 10 μM over 18-20 hours enhances the effectiveness of Meropenem in combating VIM-2 mediated antibacterial resistance, as indicated by Fractional Inhibitory Concentration (FIC) index values of 0.02 [1]. At a higher concentration of 100 μM, it also increases Meropenem's antibacterial activity against PA W35, with FIC index values of 0.125 [1]. |
Molecular Weight | 274.3 |
Formula | C12H10N4O2S |
CAS No. | 2752453-58-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Metallo-β-lactamase-IN-7 2752453-58-8 inhibitor inhibit