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BAY-297
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Catalog No. T218839 Copy Product Info
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BAY-297 is an inhibitor of PIP4K2A. It binds to PIP4K2A in both intact cells and cell lysates. BAY-297 serves as a chemical probe for studying the PIP4K2A signaling pathway and its role in physiological conditions such as cancer.
BAY-297
Cas No. 3032120-57-0
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BAY-297 is an inhibitor of PIP4K2A. It binds to PIP4K2A in both intact cells and cell lysates. BAY-297 serves as a chemical probe for studying the PIP4K2A signaling pathway and its role in physiological conditions such as cancer. |
| In vitro | BAY-297 (Compound 58) effectively inhibits recombinant PIP4K2A kinase activity in ATP consumption assays, with an IC 50 of 13 nM at (10 μM ATP) and 69 nM at (250 μM ATP). In HTRF binding competition assays, BAY-297 inhibits recombinant PIP4K2A kinase activity with an IC 50 of 110 nM at (10 μM ATP) and 769 nM at (2 mM ATP). BAY-297 engages with PIP4K2A in both THP-1 cell lysates and intact THP-1 cells with EC 50 values of 2.1 μM and 1.6 μM respectively. It inhibits CYP2C8 (IC 50 2.3 μM), CYP2C9 (IC 50 3.4 μM), and CYP3A4 (IC 50 10 μM) in human liver microsomes, showing no significant inhibition of CYP1A2 or CYP2D6. Additionally, BAY-297 inhibits hERG currents in recombinant HEK293 cells with an IC 50 of 3.1 μM. |
| Molecular Weight | 459.90 |
| Formula | C25H19ClFN5O |
| Cas No. | 3032120-57-0 |
| Smiles | N([C@@H](C(N)=O)CC)C=1C2=C(N=C(C1C#N)C3=CC=C(C=C3)C4=C(F)C(Cl)=CC=C4)C=NC=C2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: BAY-297 in vitro | BAY-297 formula | BAY-297 molecular weight
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