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Win-62005

Win-62005
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Win-62005

Catalog No. T13340Cas No. 152633-54-0
Win-62005 is an inhibitor of cyclic AMP phosphodiesterase III (PDE III)(Kis: 25 and 26 nM for rat heart and canine aorta).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
Win-62005 is an inhibitor of cyclic AMP phosphodiesterase III (PDE III)(Kis: 25 and 26 nM for rat heart and canine aorta).
In vitro
Win-62005 is a competitive inhibitor of cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) found in rat heart and canine aorta, demonstrating high affinity with inhibition constants (Ki) of approximately 25±3 nM and 26±5 nM, respectively. Furthermore, it exhibits significant selectivity, being at least 160-fold more selective for PDE III over other phosphodiesterase (PDE) isozymes.
In vivo
Win-62005(p.o. administration of 1 mg/kg) LVdP/dtmax is significantly increased in 30 min and remains increased for at least 6 h.
Chemical Properties
Molecular Weight226.23
FormulaC12H10N4O
Cas No.152633-54-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
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