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Tigemonam

Name: Tigemonam
Brand: TargetMol
SKU: T13926
Price: 553 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13926Cas No. 102507-71-1

Tigemonam is a monobactam, a novel orally administered monobactam that protects against gram-negative aerobic bacterial pathogens and is at least as active against clinical isolates of Enterobacteriaceae as amitraz or carmonan (MIC90: 0.06-16 mg/l). [3]

Tigemonam

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Purity: 97.71%

Catalog No. T13926Cas No. 102507-71-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$553	In Stock	In Stock
5 mg	$1,110	In Stock	In Stock
10 mg	$1,490	In Stock	In Stock
25 mg	$2,230	In Stock	In Stock
50 mg	$3,010	In Stock	In Stock
100 mg	$3,970	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.71%

ee:100%

Appearance:Solid

Color:White

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COA HPLC HNMR CSFC

Product Introduction

Bioactivity

Description	Tigemonam is a monobactam, a novel orally administered monobactam that protects against gram-negative aerobic bacterial pathogens and is at least as active against clinical isolates of Enterobacteriaceae as amitraz or carmonan (MIC90: 0.06-16 mg/l). [3]
In vitro	Tigemonam (0.25 mg/L) inhibits 90% of Escherichia coli, Klebsiella spp., Proteus spp., Salmonella spp., Haemophilus influenzae, and Branhamella catarrhalis. The MIC90 is 16 mg/L for Enterobacter spp. and 4 mg/L for Citrobacter. Pseudomonas aeruginosa is resistant to tigemonam but susceptible to aztreonam. Tigemonam shows minimal inoculum dependence, between 10^2 and 10^6 cfu per spot [1].
In vivo	Tigemonam demonstrates potent efficacy against a range of bacterial strains, including E. coli SC 12199, Escherichia coli SC 8294, Salmonella schottmulleri SC 3850, Proteus mirabilis SC 9575, Providencia rettgeri SC 8217, Klebsiella pneumoniae SC 12216, Serratia marcescens SC 9782, Enterobacter cloacae SC 11078, and Haemophilus influenzae SC 10556, achieving ED50 values of 1.5 mg/kg, 1.4 mg/kg, 0.7 mg/kg, 0.3 mg/kg, 0.2 mg/kg, 0.9 mg/kg, 0.5 mg/kg, 3.9 mg/kg, and 1.8 mg/kg respectively in mice.

Chemical Properties

Molecular Weight	437.41
Formula	C₁₂H₁₅N₅O₉S₂
Cas No.	102507-71-1
Smiles	N(C(/C(=N\OCC(O)=O)/C=1N=C(N)SC1)=O)[C@H]2C(C)(C)N(OS(=O)(=O)O)C2=O
Relative Density.	1.91 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (125.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2862 mL	11.4309 mL	22.8618 mL	114.3092 mL
5 mM	0.4572 mL	2.2862 mL	4.5724 mL	22.8618 mL
10 mM	0.2286 mL	1.1431 mL	2.2862 mL	11.4309 mL
20 mM	0.1143 mL	0.5715 mL	1.1431 mL	5.7155 mL
50 mM	0.0457 mL	0.2286 mL	0.4572 mL	2.2862 mL
100 mM	0.0229 mL	0.1143 mL	0.2286 mL	1.1431 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc