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Taprenepag isopropyl

Catalog No. T16988 CAS 1005549-94-9

Synonyms: PF-04217329

Taprenepag isopropyl is a highly selective agonist of the EP2 receptor.

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Taprenepag isopropyl, CAS 1005549-94-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Taprenepag isopropyl is a highly selective agonist of the EP2 receptor.

In vivo

Intraocular pressure (IOP) in the left, vehicle-dosed eye typically remains within the normal range. In the right (Taprenepag isopropyl-dosed) eye, IOP is reduced in all dose groups. In the high-dose group, IOP is reduced to the extent that it cannot be measured (<4mm Hg) on Days 22 and 29. There are no clinical signs or changes in body weight observed with any dose of Taprenepag isopropyl administration, and no ocular findings occur for animals in the low-dose group (0.75 mg/day) [1].

Synonyms	PF-04217329
Molecular Weight	520.6
Formula	C27H28N4O5S
CAS No.	1005549-94-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Yanochko GM, et al. Investigation of ocular events associated with taprenepag isopropyl, a topical EP2 agonist in development for treatment of glaucoma. J Ocul Pharmacol Ther. 2014 Jun;30(5):429-39.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Taprenepag isopropyl 1005549-94-9 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor PF-04217329 Inhibitor inhibitor inhibit

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