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TPPU

Catalog No. T7199 CAS 1222780-33-7

TPPU is a potent inhibitor of both human and mouse sEH (IC50 of 3.7 and 2.8 nM, respectively)

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TPPU, CAS 1222780-33-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
5 mg	In stock	$ 67.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 237.00
50 mg	In stock	$ 389.00
100 mg	In stock	$ 569.00
1 mL * 10 mM (in DMSO)	In stock	$ 74.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TPPU is a potent inhibitor of both human and mouse sEH (IC50 of 3.7 and 2.8 nM, respectively)
Targets&IC50	sEH (human):3.7 nM , sEH (mouse):2.8 nM
In vivo	TPPU and two 4-(cyclohexyloxy) benzoic acid urea sEHIs displayed high plasma concentrations (>10 × IC(50)), when dosed orally at 0.3 mg·kg(-1). Although the 4-(cyclohexyloxy) benzoic acid ureas were more potent against monkey sEH than piperidyl ureas (TPAU and TPPU), the latter compounds showed higher plasma concentrations and more drug-like properties. The C(max) increased with dose from 0.3 to 3 mg·kg(-1) for TPPU and from 0.1 to 3 mg·kg(-1) for TPAU, although it was not linear over this range of doses. As an indication of target engagement, ratios of linoleate epoxides to diols increased with TPPU administration[1].
Animal Research	PK parameters of 11 sEHIs in cynomolgus monkeys were determined after oral dosing with 0.3 mg/kg. Their physical properties and inhibitory potency in hepatic cytosol of cynomolgus monkeys were examined. Dose-dependent effects of the two inhibitors 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU) and the related acetyl piperidine derivative, 1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl) urea (TPAU), on natural blood eicosanoids[1]

Molecular Weight	359.34
Formula	C16H20F3N3O3
CAS No.	1222780-33-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 28 mg/mL (77.92 mM)

References and Literature

1. Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys[J]. British Journal of Pharmacology, 2012, 165. 2. Yao ES, Tang Y, Liu XH,et al.TPPU protects tau from H2O2-induced hyperphosphorylation in HEK293/tau cells by regulating PI3K/AKT/GSK-3β pathway[J].J Huazhong Univ Sci Technolog Med Sci. 2016 Dec;36(6):785-790.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Inhibitor Library Covalent Inhibitor Library Bioactive Compound Library Metabolism Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

(Rac)-EC5026 CUDA GSK2256294A sEH inhibitor-7 ARM1 1,3-Diphenylurea sEH inhibitor-16 Diflapolin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TPPU 1222780-33-7 Metabolism Epoxide Hydrolase inhibit Inhibitor inhibitor

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