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Sulfosuccinimidyl oleate

Catalog No. T13036 CAS 135661-44-8

Synonyms: Sulfo-N-succinimidyl oleate

Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Sulfosuccinimidyl oleate is neuroprotective and alleviates stroke-induced neuroinflammation [1] [2].

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Sulfosuccinimidyl oleate Chemical Structure

Sulfosuccinimidyl oleate, CAS 135661-44-8

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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Description	Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Sulfosuccinimidyl oleate is neuroprotective and alleviates stroke-induced neuroinflammation [1] [2].
In vitro	Treatment with sulfosuccinimidyl oleate (20 μM and 50 μM, 24 hours) does not affect cellular viability on its own. However, exposing BV2 cells to 100 ng/ml LPS and 5 ng/ml IFNγ slightly but significantly reduces their viability, a decrease that is prevented by co-treating with sulfosuccinimidyl oleate. Furthermore, co-treatment with sulfosuccinimidyl oleate (50 μM, 24 hours) notably reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis confirms a significant increase in phosphorylated p38 due to LPS/IFNγ, which is mitigated by co-treating with sulfosuccinimidyl oleate (50 μM, 24 hours) [1]. In summary, sulfosuccinimidyl oleate effectively counteracts the adverse effects on cell viability and inflammatory markers induced by LPS and IFNγ in BV2 cells.
In vivo	Sulfosuccinimidyl oleate (50 mg/kg; administered once via single oral gavage) significantly diminishes the size of cortical ischemic infarcts in male BALB/cABom mice subjected to the pMCAo model, showing a considerable reduction in brain damage following ischemia compared to that observed in vehicle-treated controls. At a dosage of 50 mg/kg, this compound demonstrates a beneficial effect in attenuating infarct size post-stroke, establishing its efficacy in this animal model [1].

Synonyms	Sulfo-N-succinimidyl oleate
Molecular Weight	459.6
Formula	C22H37NO7S
CAS No.	135661-44-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Drahota Z, et al. Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain. Biochem Biophys Res Commun. 2010 Jan 15;391(3):1348-51. 2. Dhungana H, et al. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. J Neuroinflammation. 2017 Dec 4;14(1):237.

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Keywords

Sulfosuccinimidyl oleate 135661-44-8 Autophagy Mitophagy inhibit Mitochondrial Autophagy Inhibitor Sulfo-N-succinimidyl oleate inhibitor

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