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Selgantolimod

Catalog No. T16870 CAS 2004677-13-6

Synonyms: GS-9688

Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.

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Selgantolimod, CAS 2004677-13-6

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Purity: 98%

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Description	Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
In vitro	Selgantolimod induces the cellular immune mediators interleukin (IL)-12 and IL-8, as well as the antiviral cytokines tumor necrosis factor-α and interferon-γ in vitro in human peripheral blood mononuclear cells. Selgantolimod-induced cytokines reduce HBV DNA, RNA, and antigen levels in HBV-infected primary human hepatocytes. Selgantolimod activates natural killer and mucosal-associated invariant T cells, stimulates cluster of differentiation (CD)-8+ T-cell proliferation, and increase IFNγ production while lowering programmed cell death protein 1 expression by HBV-specific CD8+-T cells in vitro in peripheral blood mononuclear cells [1].
In vivo	Selgantolimod (p.o., once-weekly) treatment induces dose-dependent increases in serum IL-12 and IL-1 receptor antagonist (IL-1RA) in cynomolgus monkeys and causes functional cure in the woodchuck model of chronic HBV [1].

Synonyms	GS-9688
Molecular Weight	293.34
Formula	C14H20FN5O
CAS No.	2004677-13-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Jules Levin. Efficacy and Safety of Oral TLR8 Agonist Selgantolimod in Virally Suppressed Adult Patients With Chronic Hepatitis B: a Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study. 2019 Nov 8-12. 2. Benjamin Ryan. Selgantolimod Shows Promise as Treatment for Hepatitis B. November 18, 2019. 3. Romas Geleziunas, et al. Modulators of toll-like receptors for the treatment of hiv. US20170071944A1.

Related Products

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RS 09 Teuclatriol Grossamide Capillarisin ABR-238901 CU-CPD107 Selgantolimod LPA1 receptor antagonist 1

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Keywords

Selgantolimod 2004677-13-6 免疫与炎症微生物学 TLR HBV GS-9688 Inhibitor inhibitor inhibit

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