store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Risarestat (CT-112) is a potent aldose reductase inhibitor and thyroid hormone receptor (TR) antagonist for the treatment of hypoglycemia.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 279.00 | |
5 mg | In stock | $ 693.00 | |
10 mg | In stock | $ 988.00 | |
25 mg | In stock | $ 1,460.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Risarestat (CT-112) is a potent aldose reductase inhibitor and thyroid hormone receptor (TR) antagonist for the treatment of hypoglycemia. |
In vivo | In a dose-dependent manner, Risarestat inhibits the accumulation of dulcitol, with the exception of the 1.0% solution, which exhibits activity comparable to the 0.25% solution[1]. Following instillation, Risarestat peaks in the corneal epithelium, stroma, endothelium, and aqueous humor within 30 minutes, gradually diminishing time-dependently over 24 hours. Risarestat remains detectable in the lens for up to 24 hours, with a peak concentration observed at 2 hours after instillation[2]. In the group treated with Risarestat, the anterior surface area of superficial cells significantly decreases from a mean value of 881 to 728 microns^2. Corneal sensitivity significantly improves from 5.36 to 1.37 g/mm^2[3]. Animals treated with Risarestat show a significant increase in the mean blink response compared to untreated galactose-fed rats, and the response does not differ significantly from controls toward the completion of the 7-month study. However, animals treated topically with Risarestat and untreated galactose-fed rats develop bilateral nuclear cataracts within 3 weeks[3]. |
Synonyms | CT 112 |
Molecular Weight | 323.41 |
Formula | C16H21NO4S |
CAS No. | 79714-31-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (154.60 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Risarestat 79714-31-1 Endocrinology/Hormones Metabolism Reductase CT 112 CT-112 CT112 inhibitor inhibit