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Risarestat

Name: Risarestat
Brand: TargetMol
SKU: T16756
Price: 142 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16756Cas No. 79714-31-1

Alias CT 112

Risarestat (CT-112) is a potent aldose reductase inhibitor and thyroid hormone receptor (TR) antagonist for the treatment of hypoglycemia.

Risarestat

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Purity: 98.39%

Catalog No. T16756Alias CT 112Cas No. 79714-31-1

Risarestat (CT-112) is a potent aldose reductase inhibitor and thyroid hormone receptor (TR) antagonist for the treatment of hypoglycemia.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$142	-	In Stock
5 mg	$355	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.39%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Risarestat (CT-112) is a potent aldose reductase inhibitor and thyroid hormone receptor (TR) antagonist for the treatment of hypoglycemia.
In vivo	In a dose-dependent manner, Risarestat inhibits the accumulation of dulcitol, with the exception of the 1.0% solution, which exhibits activity comparable to the 0.25% solution[1]. Following instillation, Risarestat peaks in the corneal epithelium, stroma, endothelium, and aqueous humor within 30 minutes, gradually diminishing time-dependently over 24 hours. Risarestat remains detectable in the lens for up to 24 hours, with a peak concentration observed at 2 hours after instillation[2]. In the group treated with Risarestat, the anterior surface area of superficial cells significantly decreases from a mean value of 881 to 728 microns^2. Corneal sensitivity significantly improves from 5.36 to 1.37 g/mm^2[3]. Animals treated with Risarestat show a significant increase in the mean blink response compared to untreated galactose-fed rats, and the response does not differ significantly from controls toward the completion of the 7-month study. However, animals treated topically with Risarestat and untreated galactose-fed rats develop bilateral nuclear cataracts within 3 weeks[3].
Synonyms	CT 112

Chemical Properties

Molecular Weight	323.41
Formula	C₁₆H₂₁NO₄S
Cas No.	79714-31-1
Smiles	CCCCCOc1ccc(cc1OCC)C1SC(=O)NC1=O
Relative Density.	1.189 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (154.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (15.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0921 mL	15.4603 mL	30.9205 mL	154.6025 mL
5 mM	0.6184 mL	3.0921 mL	6.1841 mL	30.9205 mL
10 mM	0.3092 mL	1.5460 mL	3.0921 mL	15.4603 mL
20 mM	0.1546 mL	0.7730 mL	1.5460 mL	7.7301 mL
50 mM	0.0618 mL	0.3092 mL	0.6184 mL	3.0921 mL
100 mM	0.0309 mL	0.1546 mL	0.3092 mL	1.5460 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc