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Procyanidol B4

Catalog No. TN1151 CAS 29106-51-2

Synonyms: Procyanidin B4

Procyanidin B4 reveals significant Antioxidant activity

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Procyanidol B4, CAS 29106-51-2

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Purity: 98%

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Description

Procyanidin B4 reveals significant antioxidant activity

In vitro

Aimed to isolate and purify the proanthocyanidins from lotus seed skin by acetone extraction and rotary evaporation, identify their chemical structures by HPLC-MS-MS and NMR, and further investigate the antioxidant properties of the extract purified by macroporous resin (PMR) from lotus seed skin both in vitro and in vivo. The results showed that PMR mainly contained oligomeric proanthocyanidins, especially dimeric procyanidin B1 (PB1), procyanidin B2 and Procyanidin B4. Although it had limited ability to directly scavenge radicals in vitro, PMR could significantly enhance the expressions of antioxidant proteins via activation of nuclear factor-E2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway in HepG2 cells. Molecular data revealed that PB1, a major component in PMR, stabilized Nrf2 by inhibiting the ubiquitination of Nrf2, which led to subsequent activation of the Nrf2-ARE pathway, including the enhancements of Nrf2 nuclear translocation, Nrf2-ARE binding and ARE transcriptional activity. Moreover, the in vivo results in high fat diet-induced mice further verified the powerful antioxidant property of PMR[1]

Synonyms	Procyanidin B4
Molecular Weight	578.52
Formula	C30H26O12
CAS No.	29106-51-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway.Acta Biochim Biophys Sin (Shanghai). 2019 Jan 1;51(1):31-40.

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Keywords

Procyanidol B4 29106-51-2 Immunology/Inflammation Nrf2 Procyanidin B4 Procyanidol B-4 Inhibitor inhibitor inhibit

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