Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Prinoxodan is an inhibitor of phosphodiesterase.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Prinoxodan is an inhibitor of phosphodiesterase. |
In vitro | Prinoxodan is an agent of orally effective positive inotropic/vasodilator. Prinoxodan is a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent is examined in vitro in isolated guinea pig hearts; in the latter, Prinoxodan 5 nmol-5 μmol increases contractility in a dose-related fashion[2]. |
In vivo | Prinoxodan (i.v.) treat to anesthetized dogs increases contractile force while decreasing arterial pressure and total peripheral resistance (TPR) in a dose-related manner. Heart rate (HR) is only slightly increased, and aortic flow is not appreciably altered. A single oral dose of Prinoxodan 0.3 mg/kg administered to conscious chronically instrumented dogs produces a marked and sustained increase in contractility 15-240 min after treatment while only slightly increasing HR. The effects of Prinoxodan 30-300 μg/kg, i.v. are studied in a mecamylamine-propranolol-induced model of heart failure. Prinoxodan effectively reverses the drug-induced heart failure by increasing myocardial contractility and decreasing arterial pressure while only slightly affecting HR[2]. |
Synonyms | RGW2938 |
Molecular Weight | 258.28 |
Formula | C13H14N4O2 |
CAS No. | 111786-07-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Prinoxodan 111786-07-3 Others RGW 2938 RGW2938 RGW-2938 inhibitor inhibit