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Pentetic Acid
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Catalog No. T0420Cas No. 67-43-6
Alias DTPA, diethylenetriaminepentaacetic acid, Detarex, Detapac, Acidum penteticum
Pentetic Acid (Detarex) is an edetate and a chelating agent used in preparing radiopharmaceuticals.
Pentetic Acid
Copy Product Info🥰Excellent
Catalog No. T0420Alias DTPA, diethylenetriaminepentaacetic acid, Detarex, Detapac, Acidum penteticumCas No. 67-43-6
Pentetic Acid (Detarex) is an edetate and a chelating agent used in preparing radiopharmaceuticals.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $41 | In Stock | In Stock | |
| 200 mg | $56 | In Stock | In Stock | |
| 500 mg | $91 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:≥95%
Appearance:Solid
Color:White
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Product Introduction
Pentetic Acid AI Summary
Pentetic Acid demonstrates various dissociation constants (pKa values) ranging from 2.0 to 10.48 at 25 degrees Celsius, indicative of its potential ionization and acidity characteristics. It shows a high stability constant (log K = 22.4) for Yttrium(III) and Gadolinium(III), suggesting strong chelating properties. The compound has notable biodistribution in tissues such as tumors, liver, and kidneys when tested in mice and rats, indicating its potential for targeted imaging or therapeutic applications. In cytotoxicity assays, it exhibits an IC50 value of 264500.0 nM against human HeLa cells and 39100.0 nM against human HT29 cells, while showing antiproliferative activity against human HepG2 cells with an IC50 value of 38300.0 nM. Additionally, Pentetic Acid displays a broad spectrum of bioactivities, inhibiting various enzymes such as Human Jumonji Domain Containing 2E (JMJD2E), Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Giardia Lamblia's Fructose-1,6-bisphosphate Aldolase, among others. It also exhibits antimicrobial and antiviral activities, including against SARS-CoV-2 with IC50 values indicating moderate to weak potency. Moreover, it shows metal chelating activity with a significant stability constant of Fe3+-compound complex (log K = 28.6). The compound exhibits minimal toxicity, evidenced by the absence of drug-induced liver injury in humans and only low inhibition of cell viability in SARS-CoV-2 infected Vero E6 cells. Finally, it interacts with multiple receptors and enzymes with varying degrees of inhibition and activation, signifying its versatile bioactivity profile..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Pentetic Acid (Detarex) is an edetate and a chelating agent used in preparing radiopharmaceuticals. |
| Synonyms | DTPA, diethylenetriaminepentaacetic acid, Detarex, Detapac, Acidum penteticum |
| Molecular Weight | 393.35 |
| Formula | C14H23N3O10 |
| Cas No. | 67-43-6 |
| Smiles | OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O |
| Relative Density. | Ca. 625 g/L. Temperature:20 °C. |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 1.17 mg/mL (2.97 mM), Sonication is recommended.  | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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