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NSC668394

Catalog No. T28212 CAS 382605-72-3

Synonyms: NSC-668394, NSC 668394

NSC668394 is a potent small molecule ezrin (Thr567) phosphorylation inhibitor.NSC668394 has potential antitumor activity by inhibiting ezrin T567 phosphorylation and increasing Ca2+-dependent ezrin cleavage.NSC668394 can be used to study tumor metastasis.

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NSC668394, CAS 382605-72-3

Pack Size	Availability	Price/USD	Quantity
1 mg	In stock	$ 69.00
5 mg	In stock	$ 199.00

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Purity: 99.29%

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Description	NSC668394 is a potent small molecule ezrin (Thr567) phosphorylation inhibitor.NSC668394 has potential antitumor activity by inhibiting ezrin T567 phosphorylation and increasing Ca2+-dependent ezrin cleavage.NSC668394 can be used to study tumor metastasis.
Targets&IC50	Ezrin T567:8.1 μM
In vitro	NSC668394, when pretreated at 10 μM for 15 minutes, inhibits ezrin T567 phosphorylation (IC50=8.1 μM) and in vitro actin binding[2]. Additionally, at concentrations ranging from 1 to 10 μM for 2 to 6 hours, NSC668394 inhibits ezrin-mediated invasion of K7M2 osteosarcoma (OS) cells into HUVEC monolayers[2]. Furthermore, at a concentration of 20 μM, NSC668394 significantly reduces the growth of JM1 and JM2 rat hepatocellular carcinoma cell lines[1]. Notably, NSC668394 at 10 μM diminishes cell motility phenotypes in zebrafish[2].
In vivo	Administered at a dose of 0.226 mg/kg/day through weekly intraperitoneal injections for 5 days, NSC668394 inhibits ezrin protein-dependent in vivo metastatic growth in the lungs of mice[2].

Synonyms	NSC-668394, NSC 668394
Molecular Weight	452.1
Formula	C17H12Br2N2O3
CAS No.	382605-72-3

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL(66.36 mM), Sonication is recommended.

References and Literature

1. Xue Y, et, al. Phosphorylated Ezrin (Thr567) Regulates Hippo Pathway and Yes-Associated Protein (Yap) in Liver. Am J Pathol. 2020 Jul;190(7):1427-1437. 2. Bulut G, et, al. Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells. Oncogene. 2012 Jan 19;31(3):269-81. 3. Çelik H, et, al. Ezrin Inhibition Up-regulates Stress Response Gene Expression. J Biol Chem. 2016 Jun 17;291(25):13257-70.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library

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Keywords

NSC668394 382605-72-3 Chromatin/Epigenetic Cytoskeletal Signaling PKC NSC-668394 NSC 668394 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.