Powder: -20°C for 3 years | In solvent: -80°C for 1 year
N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker employed in the synthesis of PROTACs and antibody-drug conjugates (ADCs) [1, 2]. It acts as a cleavable ADC linker, facilitating the conjugation of drugs to antibodies for targeted delivery [2].
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100 mg | 5 days | Inquiry | |
500 mg | 5 days | Inquiry |
Description | N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker employed in the synthesis of PROTACs and antibody-drug conjugates (ADCs) [1, 2]. It acts as a cleavable ADC linker, facilitating the conjugation of drugs to antibodies for targeted delivery [2]. |
In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
Synonyms | 3-(2-Bromoacetamido)propanoic acid NHS ester |
Molecular Weight | 307.1 |
Formula | C9H11BrN2O5 |
CAS No. | 57159-62-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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N-Succinimidyl 3-(Bromoacetamido)propionate 57159-62-3 Others 3-(2-Bromoacetamido)propanoic acid NHS ester N Succinimidyl 3 (Bromoacetamido)propionate NSuccinimidyl 3(Bromoacetamido)propionate inhibitor inhibit