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Miriplatin hydrate

Catalog No. T21297 CAS 250159-48-9

Synonyms: SM-11355 (hydrate)

Miriplatin hydrate (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC). Miriplatin hydrate is a lipophilic platinum complex that can be easily suspended in Lipiodol and gradually releases active platinum compounds in tumor tissue.

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Miriplatin hydrate, CAS 250159-48-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	SM-11355 (hydrate)
Molecular Weight	782.01
Formula	C34H70N2O5Pt
CAS No.	250159-48-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: Insoluble

DMSO: Soluble, DMSO can inactivate Miriplatin's activity

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Yasui D, et al. Improved efficacy of transcatheter arterial chemoembolization using warmed miriplatin for hepatocellular carcinoma. Biomed Res Int. 2014;2014:359296. 2. Arai H, et al. Safety and efficacy of balloon-occluded transcatheter arterial chemoembolization using miriplatin for hepatocellular carcinoma. Hepatol Res. 2014 Aug 8. 3. Ishikawa T, et al. Predictive factor of local recurrence after balloon-occluded TACE with miriplatin (MPT) in hepatocellular carcinoma. PLoS One. 2014 Jul 21;9(7):e103009. 4. Ito T, Okubo H, Kokubu S, Miyazaki A, Ando H, Fujimura A, Watanabe S. Radiofrequency ablation combined with chemolipiodolization in a porcine liver: Comparison of the pharmacokinetic analysis with cisplatin powder and miriplatin. Hepatol Res. 2014 Jul 7. doi: 10.1111/hepr.12387. [Epub ahead of print] PubMed PMID: 25040841.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Miriplatin hydrate 250159-48-9 DNA Damage/DNA Repair DNA Alkylation SM-11355 (hydrate) Inhibitor inhibitor inhibit

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