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MK-0773

Catalog No. T16090 CAS 606101-58-0

Synonyms: PF-05314882

MK-0773 (PF-05314882) is a selective androgen receptor modulator that binds to AR (IC50: 6.6 nM) for the study of diseases caused by endocrine abnormalities.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MK-0773, CAS 606101-58-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 78.00
5 mg	In stock	$ 188.00
10 mg	In stock	$ 289.00
1 mL * 10 mM (in DMSO)	In stock	$ 196.00

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Purity: 99.63%

Purity: 99.36%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MK-0773 (PF-05314882) is a selective androgen receptor modulator that binds to AR (IC50: 6.6 nM) for the study of diseases caused by endocrine abnormalities.
Targets&IC50	Androgen receptor:6.6 nM
In vitro	The affinity of MK-0773 for AR across species can be evaluated using COS cells transfected with AR, with respective IC50 values as follows: rat, 0.50 nM; dog, 0.55 nM; rhesus, 0.45 nM; human, 0.65 nM[1].
In vivo	Treatment of OVX rats with MK-0773 (5 mg/kg, 25 mg/kg), 2-FPA, TFM-4AS-1, and DHT for 24 days resulted in a decrease in total cholesterol and high-density lipoprotein by 25-37%[1].

Synonyms	PF-05314882
Molecular Weight	479.59
Formula	C27H34FN5O2
CAS No.	606101-58-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (41.70 mM), Sonication is recommended.

References and Literature

1. Schmidt A, et al. Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology. J Biol Chem. 2010 May 28;285

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MK-0773 606101-58-0 Endocrinology/Hormones Androgen Receptor PF05314882 MK0773 MK 0773 PF-05314882 PF 05314882 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.