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MIR96-IN-1

Catalog No. T16077 CAS 1311982-88-3

MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.

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MIR96-IN-1, CAS 1311982-88-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.

In vitro

MIR96-IN-1 inhibits Drosha cleavage of pri-miR-96, as evidenced by an increase in the levels of pri-miR-96 and a reduction in levels of pre- and mature miR-96 in treated cells, as expected if MIR96-IN-1 binds to the Drosha site. MIR96-IN-1 efficiently and selectively silences production of miR-96 at 40 μM while not affecting miR-182 or -183. MIR96-IN-1 inhibits biogenesis of its target precursor miRNA to varying extents: MIR96-IN-1 reduces the expression level of miR-96 by 90% at 40 μM [1].

Molecular Weight	588.79
Formula	C33H48N8O2
CAS No.	1311982-88-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (169.84 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Velagapudi SP, et al. Sequence-based design of bioactive small molecules that target precursor microRNAs. Nat Chem Biol. 2014 Apr;10(4):291-7. 2. Haga CL, et al. Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling. ACS Chem Biol. 2015 Oct 16;10(10):2267-76. 3. Velagapudi SP, et al. Defining the RNA internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysis. J Am Chem Soc. 2011 Jul 6;133(26):10111-8.

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Keywords

MIR96-IN-1 1311982-88-3 免疫与炎症 MALT MIR96 IN 1 MIR-96-IN-1 MIR96IN1 Inhibitor inhibitor inhibit

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