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MIR96-IN-1

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MIR96-IN-1

Catalog No. T16077Cas No. 1311982-88-3

MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

Pack Size	Price	Availability
5 mg	$289	6-8 weeks
25 mg	$954	6-8 weeks
50 mg	$1,240	6-8 weeks
100 mg	$1,740	6-8 weeks
1 mL x 10 mM (in DMSO)	$391	6-8 weeks

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Product Introduction

Bioactivity

Description

MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.

In vitro

MIR96-IN-1 inhibits Drosha cleavage of pri-miR-96, as evidenced by an increase in the levels of pri-miR-96 and a reduction in levels of pre- and mature miR-96 in treated cells, as expected if MIR96-IN-1 binds to the Drosha site. MIR96-IN-1 efficiently and selectively silences production of miR-96 at 40 μM while not affecting miR-182 or -183. MIR96-IN-1 inhibits biogenesis of its target precursor miRNA to varying extents: MIR96-IN-1 reduces the expression level of miR-96 by 90% at 40 μM [1].

Chemical Properties

Molecular Weight	588.79
Formula	C33H48N8O2
Cas No.	1311982-88-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (169.84 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6984 mL	8.4920 mL	16.9840 mL	84.9199 mL
5 mM	0.3397 mL	1.6984 mL	3.3968 mL	16.9840 mL
10 mM	0.1698 mL	0.8492 mL	1.6984 mL	8.4920 mL
20 mM	0.0849 mL	0.4246 mL	0.8492 mL	4.2460 mL
50 mM	0.0340 mL	0.1698 mL	0.3397 mL	1.6984 mL
100 mM	0.0170 mL	0.0849 mL	0.1698 mL	0.8492 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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