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Leupeptin

Catalog No. T6564L   CAS 24365-47-7
Synonyms: Leupeptin Ac-LL, NK-381

Leupeptin is a competitive protease inhibitor produced by actinomycetes. Leupeptin can inhibit cysteine, serine and threonine peptidases. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine proteinases (papain, cathepsin B (Ki = 4.1 nM), endoproteinase Lys-C). Leupeptin does not inhibit α-chymotrypsin or thrombin.

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Leupeptin Chemical Structure
Leupeptin, CAS 24365-47-7
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25 mg Inquiry $ 1,520.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Leupeptin is a competitive protease inhibitor produced by actinomycetes. Leupeptin can inhibit cysteine, serine and threonine peptidases. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine proteinases (papain, cathepsin B (Ki = 4.1 nM), endoproteinase Lys-C). Leupeptin does not inhibit α-chymotrypsin or thrombin.
Synonyms Leupeptin Ac-LL, NK-381
Molecular Weight 426.562
Formula C20H38N6O4
CAS No. 24365-47-7

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Sharma P, Rayavara K, Ito D, Basore K, Desai SA. A CLAG3 mutation in an amphipathic transmembrane domain alters malaria parasite nutrient channels and confers leupeptin resistance. Infect Immun. 2015 Jun;83(6):2566-74. doi: 10.1128/IAI.02966-14. Epub 2015 Apr 13. PubMed PMID: 25870226; PubMed Central PMCID: PMC4432768. 2. Childers MK, Bogan JR, Bogan DJ, Greiner H, Holder M, Grange RW, Kornegay JN. Chronic administration of a leupeptin-derived calpain inhibitor fails to ameliorate severe muscle pathology in a canine model of duchenne muscular dystrophy. Front Pharmacol. 2012 Jan 9;2:89. doi: 10.3389/fphar.2011.00089. eCollection 2011. PubMed PMID: 22291646; PubMed Central PMCID: PMC3253583. 3. Gavriel H, Shulman A, Stracher A, Sohmer H. Leupeptin reduces impulse noise induced hearing loss. J Occup Med Toxicol. 2011 Dec 29;6:38. doi: 10.1186/1745-6673-6-38. PubMed PMID: 22206578; PubMed Central PMCID: PMC3286414. 4. Hausott B, Vallant N, Hochfilzer M, Mangger S, Irschick R, Haugsten EM, Klimaschewski L. Leupeptin enhances cell surface localization of fibroblast growth factor receptor 1 in adult sensory neurons by increased recycling. Eur J Cell Biol. 2012 Feb;91(2):129-38. doi: 10.1016/j.ejcb.2011.09.009. Epub 2011 Dec 9. PubMed PMID: 22169219.

TargetMolCitations

1. Hu J, Zhu Z, Chen Z, et al. Alteration in Rab11‐mediated endocytic trafficking of LDL receptor contributes to angiotensin II‐induced cholesterol accumulation and injury in podocytes. Cell Proliferation. 2022: e13229

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Keywords

Leupeptin 24365-47-7 NK 381 Leupeptin Ac-LL NK381 NK-381 inhibitor inhibit

 

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