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Lactisole

Catalog No. T35795 CAS 150436-68-3

Synonyms: na-PMP

Lactisole (na-PMP) is an inhibitor of the glucose-sensing receptor

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Lactisole, CAS 150436-68-3

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 35.00
1 mL * 10 mM (in DMSO)	In stock	$ 55.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Lactisole (na-PMP) is an inhibitor of the glucose-sensing receptor
Targets&IC50	Sweet taste receptor:∼4 mM
In vitro	In MIN6 cells, in a dose-dependent manner, lactisole inhibited insulin secretion induced by sweeteners, acesulfame-K, sucralose and glycyrrhizin. The IC50 was ～4 mmol/l. Lactisole attenuated the elevation of cytoplasmic Ca2+ concentration ([Ca2+]c) evoked by sucralose and acesulfame-K but did not affect the elevation of intracellular cAMP concentration ([cAMP]c) induced by these sweeteners. Lactisole also inhibited the action of glucose in MIN6 cells. Thus, lactisole significantly reduced elevations of intracellular [NADH] and intracellular [ATP] induced by glucose, and also inhibited glucose-induced insulin secretion[1].

Synonyms	na-PMP
Molecular Weight	218.18
Formula	C10H11NaO4
CAS No.	150436-68-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 1 mg/mL

DMSO: 10 mg/mL

DMF: 20 mg/mL

References and Literature

1. Johnson, C., Birch, G.G., and MacDougall, D.B. The effect of the sweetness inhibitor 2(-4-methoxyphenoxy)propanoic acid (sodium salt) (Na-PMP) on the taste of bitter-sweet stimuli. Chem.Senses 19(4), 348-358 (1994). 2. Schiffman, S.S., Booth, B.J., Sattely-Miller, E.A., et al. Selective inhibition of sweetness by the sodium salt of ±2-(4-methoxyphenoxy)propanoic acid. Chem.Senses 24(4), 439-447 (1999). 3. Hamano, K., Nakagawa, Y., Ohtsu, Y., et al. Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic β-cells. Journal of Endocrinology 226(1), 57-66 (2015). 4. Shim, J., Son, H.J., Kim, Y., et al. Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2. PLoS One 10(4), (2015). 5. Ohtsu, Y., Nakagawa, Y., Nagasawa, M., et al. Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells. Molecular and Cellular Endocrinology 394(1-2), 70-79 (2014). 6. Sato, S., Hokari, R., Kurihara, C., et al. Dietary lipids and sweeteners regulate glucagon-like peptide-2 secretion. Am. J. Physiol Gastrointest. Liver Physiol. 304(8), 304-308 (2013).

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Bioactive Compound Library Clinical Compound Library Food Additive Library Metabolism Compound Library Bioactive Compounds Library Max

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Keywords

Lactisole 150436-68-3 Metabolism Taste receptor na-PMP inhibitor inhibit

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