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KU-2285

Catalog No. T32427 CAS 121077-11-0

Synonyms: KU 2285

KU-2285 is a potent hypoxic cell radiosensitizer. At less than 100 mg/kg, KU-2285 sensitized SCCVII tumors more than MISO and SR-2508 by fractionated irradiation. KU-2285 entered clinical trials in late 1990s.

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KU-2285, CAS 121077-11-0

Pack Size	Availability	Price/USD
25 mg	In stock	$ 1,520.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	KU 2285
Molecular Weight	264.19
Formula	C8H10F2N4O4
CAS No.	121077-11-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Shibamoto Y, Ohshio G, Hosotani R, Nishimura Y, Manabe T, Imamura M, Abe M. A phase I/II study of a hypoxic cell radiosensitizer KU-2285 in combination with intraoperative radiotherapy. Br J Cancer. 1997;76(11):1474-9. PubMed PMID: 9400944; PubMed Central PMCID: PMC2228186. 2. Shibamoto Y, Takahashi M, Abe M. A phase I study of a hypoxic cell sensitizer KU-2285 in combination with conventional radiotherapy. Radiother Oncol. 1996 Jul;40(1):55-8. PubMed PMID: 8844888. 3. Shibata T, Shibamoto Y, Sasai K, Oya N, Murata R, Takagi T, Hiraoka M, Abe M. Comparison of in vivo efficacy of hypoxic cytotoxin tirapazamine and hypoxic cell radiosensitizer KU-2285 in combination with single and fractionated irradiation. Jpn J Cancer Res. 1996 Jan;87(1):98-104. PubMed PMID: 8609056. 4. Oya N, Shibamoto Y, Shibata T, Murata R, Iwai H, Sugiyama T, Abe M. KIN-804 vs. KU-2285 as a radiosensitizer for clinical use. Int J Radiat Oncol Biol Phys. 1994 Jun 15;29(3):595-600. PubMed PMID: 8005822.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KU-2285 121077-11-0 KU2285 KU 2285 inhibitor inhibit

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