Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ-54166060 is a potent and selective antagonist of P2X7 receptor, with IC 50 s of 4/115/72 nM for human/rat/mouse P2X7 receptor, respectively [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | JNJ-54166060 is a potent and selective antagonist of P2X7 receptor, with IC 50 s of 4/115/72 nM for human/rat/mouse P2X7 receptor, respectively [1]. |
In vivo | JNJ-54166060 demonstrates significant effectiveness across various animal models, with high oral bioavailability observed in rats (55%), dogs (>100%), and monkeys (54%), alongside considerable maximum plasma concentrations (C max) of 375 ng/mL, 1249 ng/mL, and 389 ng/mL, respectively, following a 5 mg/kg oral dose. Intravenously administered at 1 mg/kg, the compound showed low to moderate clearance rates, resulting in terminal elimination half-lives of 1.7 hours in rats, 11.9 hours in dogs, and 4.2 hours in monkeys. These pharmacokinetic parameters indicate the compound's potent and durable presence in systemic circulation across different species, underscoring its potential for further therapeutic development. |
Molecular Weight | 438.81 |
Formula | C20H15ClF4N4O |
CAS No. | 1627900-41-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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JNJ-54166060 1627900-41-7 JNJ 54166060 JNJ54166060 inhibitor inhibit