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Imidacloprid

Catalog No. T6969 CAS 138261-41-3

Imidacloprid is a systemic chloronicotinyl insecticide, which can be effectively used in agriculture to control pests .

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Imidacloprid, CAS 138261-41-3

Pack Size	Availability	Price/USD
50 mg	In stock	$ 39.00
100 mg	In stock	$ 53.00
200 mg	In stock	$ 81.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.97%

Purity: 99.85%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Imidacloprid is a systemic chloronicotinyl insecticide, which can be effectively used in agriculture to control pests .

In vitro

Three different cell models were used;?adipocytes (3T3-L1), hepatocytes (HepG2), and myotubes (C2C12).?These cells were treated with imidacloprid (0, 10, and 20 μM) for 4-6 days followed by treatment with insulin for 15 min to determine responses.?Insulin stimulated glucose uptake was reduced by imidacloprid in all three cell culture models.?Treatment with imidacloprid reduced phosphorylation of protein kinase B (AKT), one of the major regulators of insulin signaling, without changing overall AKT expression.?Subsequently, imidacloprid reduced phosphorylation of ribosomal S6 kinase (S6K), which is a downstream target of AKT and also a feed-back inhibitor of insulin signaling.?Suggest that imidacloprid could induce insulin resistance by affecting the insulin signaling cascade, particularly up-stream of AKT, in adipocytes, liver, and muscle[1].

Molecular Weight	255.66
Formula	C9H10ClN5O2
CAS No.	138261-41-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 300 mg/mL (1173.43 mM)

References and Literature

1. Kim J , Park Y , Yoon K S , et al. Imidacloprid, a neonicotinoid insecticide, induces insulin resistance[J]. The Journal of Toxicological Sciences, 2013, 38(5):655-660. 2. Crosby E B , Bailey J M , Oliveri A N , et al. Neurobehavioral impairments caused by developmental imidacloprid exposure in zebrafish[J]. Neurotoxicology and Teratology, 2015, 49:81-90. 3. Li Y, Sun H, Tian Z, et al. The determination of Plutella xylostella (L.) GSTs (PxGSTs) involved in the detoxification metabolism of Tolfenpyrad[J]. Pest Management Science. 2020.

Citations

1. Li Y, Sun H, Tian Z, et al. The determination of Plutella xylostella (L.) GSTs (PxGSTs) involved in the detoxification metabolism of Tolfenpyrad. Pest Management Science. 2020

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library FDA-Approved & Pharmacopeia Drug Library Human Metabolite Library ReFRAME Related Library Bioactive Compound Library Bioactive Compounds Library Max Covalent Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Imidacloprid 138261-41-3 Others Inhibitor inhibit inhibitor

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