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I2906

Catalog No. T11594 CAS 331963-29-2

I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis.

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I2906, CAS 331963-29-2

Pack Size	Availability	Price/USD
10 mg	5 days	$ 32.00
25 mg	5 days	$ 49.00
50 mg	5 days	$ 91.00
1 mL * 10 mM (in DMSO)	5 days	$ 119.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis.
In vitro	In vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity.
In vivo	In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, the survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05).

Molecular Weight	443.58
Formula	C25H37N3O4
CAS No.	331963-29-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lu, Jingning; Yue, Jun; Wu, Jing et al. In vitro and in vivo Activities of a New Lead Compound I2906 against Mycobacterium tuberculosis. Pharmacology (2010), 85(6), 365-371.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

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Step Two: Enter the in vivo formulation

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

I2906 331963-29-2 Others I 2906 I-2906 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.