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HJC0152 hydrochloride

Catalog No. T4234 CAS 1420290-99-8

Synonyms: HJC0152

HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.

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HJC0152 hydrochloride Chemical Structure

HJC0152 hydrochloride, CAS 1420290-99-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 33.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 63.00
10 mg	In stock	$ 93.00
25 mg	In stock	$ 191.00
50 mg	In stock	$ 321.00
200 mg	In stock	$ 598.00
500 mg	In stock	$ 956.00
1 mL * 10 mM (in DMSO)	In stock	$ 63.00

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Purity: 98.62%

Purity: 98.33%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.
In vitro	HJC0152 inhibits STAT3 promoter activity in MDA-MB-231 cells in a dose-dependent manner. It has a comparable potency in downregulating STAT3 protein production and phosphorylation at the Tyr-705 site. HJC0152 induces cleaved caspase-3 and downregulated cyclin D1 in MDA-MB-231 cells, inhibits cell cycle progression and promotes apoptosis. HJC0152 treatment efficiently suppresses HNSCC cell proliferation, arrests the cell cycle at the G0/G1 phase, induces apoptosis, and reduced cell invasion in both SCC25 and CAL27 cell lines. Moreover, HJC0152 inhibits nuclear translocation of phosphorylated STAT3 at Tyr705 and decreases VHL/β-catenin signaling activity via regulation of microRNA-21.
In vivo	HJC0152 significantly suppresses MDA-MB-231 xenograft tumor growth in vivo (ip and po), indicating its great potential as efficacious and orally bioavailable therapeutics for human cancer. It has an improved oral bioavailability and an enhanced suppression of tumor growth in mice. HJC0152 does not show significant signs of toxicity at a dose of 75 mg/kg. In SCC25-derived orthotopic mouse models, HJC0152 treatment significantly abrogates STAT3/β-catenin expression in vivo, which leading to a global decrease of tumor growth and invasion.

Synonyms	HJC0152
Molecular Weight	406.64
Formula	C15H14Cl3N3O4
CAS No.	1420290-99-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 82 mg/mL (201.7 mM)

References and Literature

1. Chen H, et al. Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents. ACS Med Chem Lett. 2013 Feb 14;4(2):180-185. 2. Wang Y, et al. Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/β-catenin Axis with HJC20152. Mol Cancer Ther. 2017, 16(4):578-590. 3. Chen C, Lu M, Lin S, et al. The nuclear gene rpl18 regulates erythroid maturation via JAK2-STAT3 signaling in zebrafish model of Diamond–Blackfan anemia[J]. Cell Death & Disease. 2020, 11(2): 1-11.

Citations

1. Chen C, Lu M, Lin S, et al. The nuclear gene rpl18 regulates erythroid maturation via JAK2-STAT3 signaling in zebrafish model of Diamond–Blackfan anemia. Cell Death & Disease. 2020, 11(2): 1-11

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Aging Compound Library Anti-Cancer Compound Library Bioactive Compound Library JAK-STAT Compound Library Anti-Cancer Metabolism Compound Library Bioactive Compounds Library Max Anti-Colorectal Cancer Compound Library Anti-Prostate Cancer Compound Library Reprogramming Compound Library

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Keywords

HJC0152 hydrochloride 1420290-99-8 Apoptosis JAK/STAT signaling Stem Cells STAT Inhibitor HJC0152 Hydrochloride HJC-0152 HJC0152 HJC 0152 Hydrochloride HJC-0152 Hydrochloride inhibit HJC 0152 HJC-0152 hydrochloride inhibitor

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