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HDAC-IN-4

Catalog No. T11542   CAS 1252003-13-6

HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.

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HDAC-IN-4 Chemical Structure
HDAC-IN-4, CAS 1252003-13-6
Pack Size Availability Price/USD Quantity
1 mg 5 days $ 49.00
1 mL * 10 mM (in DMSO) 5 days $ 161.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.
Targets&IC50 HDAC6:7.2(pIC50)
In vitro HDAC-IN-4 is more potent against HDAC6 than Tubastatin A, suggests that HDAC-IN-4 may be a better HDAC6 probe than Tubastatin A.HDAC-IN-4 inhibits HDAC1, HDAC2, HDAC3, HDAC8 and HDAC10 with pIC50s of 5.5, 4.6, 5.4, 5.4, 6.7 in FRET assay, respectively.
Molecular Weight 335.4
Formula C20H21N3O2
CAS No. 1252003-13-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

TargetMolReferences and Literature

1. Géraldy M, et al. Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated. J Med Chem. 2019 May 9;62(9):4426-4443.

TargetMolCitations

1. Sun L, Zhang Y, Cai J, et al.Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer.Nature Communications.2023, 14(1): 755.

Related Products

Related compounds with same targets
JPS014 TFA JPS016 TFA NT160 HDAC-IN-59 HDAC-IN-60 HDAC6-IN-16 HDAC6-IN-17 BChE/HDAC6-IN-1

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Keywords

HDAC-IN-4 1252003-13-6 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC HDACIN4 HDAC IN 4 inhibitor inhibit

 

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