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G-5555 hydrochloride (1648863-90-4 free base)

Catalog No. T11342   CAS T11342
Synonyms: G-5555 hydrochloride

G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.

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G-5555 hydrochloride (1648863-90-4 free base) Chemical Structure
G-5555 hydrochloride (1648863-90-4 free base), CAS T11342
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Biological Description
Chemical Properties
Storage & Solubility Information
Description G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.
Targets&IC50 PAK2:11 nM (ki), PAK1:3.7 nM (ki)
Synonyms G-5555 hydrochloride
Molecular Weight 529.42
Formula C25H26Cl2N6O3
CAS No. T11342

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (188.89 mM), sonification is recommended.

H2O: 16.67 mg/mL (31.49 mM), sonification is recommended.

TargetMolReferences and Literature

1. Ndubaku CO, et al. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6. 2. Rudolph J, et al. Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem. 2016 Jun 9;59(11):5520-41.

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5-Aminosalicylic Acid FRAX486 LCH-7749944 KPT9274 PAK4-IN-3 FRAX486 HCL(1232030-35-1 free base) IPA-3 AZ13705339

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Keywords

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