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Ethyl 3,4,5-trimethoxybenzoate

Name: Ethyl 3,4,5-trimethoxybenzoate
Brand: TargetMol
SKU: TN4017
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN4017 Copy Product Info

Purity: 99.81%

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Ethyl 3,4,5-trimethoxybenzoate is a natural product derived from Rauvolfia verticillata.

Cas No. 6178-44-5

Pack Size	Price	USA Stock	Global Stock	Quantity
5 g	$40	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.81%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description

Ethyl 3,4,5-trimethoxybenzoate is a natural product derived from Rauvolfia verticillata.

In vitro

Method: B16F10 mouse melanoma cells were treated with ethyl 3,4,5-trimethoxybenzoate at concentrations of 2, 5, 10, 25, 50, or 100 μg/mL for 24, 48, or 72 h, and cell viability was evaluated using the MTS assay.
Rresult: Cell viability generally remained around or above 80% under the tested conditions, whereas higher concentrations, particularly concentrations of at least 25 μg/mL, showed a greater cytotoxic tendency. Concentrations of 2–10 μg/mL were therefore used in subsequent activity assays.[1]
Method: B16F10 mouse melanoma cells were stimulated with α-melanocyte-stimulating hormone and treated with ethyl 3,4,5-trimethoxybenzoate at concentrations of 0, 2, 5, or 10 μg/mL for 72 h. Tyrosinase protein expression was analyzed by Western blotting and normalized to HSP90.
Rresult: Ethyl 3,4,5-trimethoxybenzoate reduced cellular tyrosinase protein expression, and treatment at 10 μg/mL produced a marked reduction that was greater than that observed with 125 μg/mL arbutin.[1]

Chemical Properties

Molecular Weight	240.25
Formula	C₁₂H₁₆O₅
Cas No.	6178-44-5
Smiles	O=C(OCC)C1=CC(OC)=C(OC)C(OC)=C1
Relative Density.	1.113 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (332.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1623 mL	20.8117 mL	41.6233 mL	208.1165 mL
5 mM	0.8325 mL	4.1623 mL	8.3247 mL	41.6233 mL
10 mM	0.4162 mL	2.0812 mL	4.1623 mL	20.8117 mL
20 mM	0.2081 mL	1.0406 mL	2.0812 mL	10.4058 mL
50 mM	0.0832 mL	0.4162 mL	0.8325 mL	4.1623 mL
100 mM	0.0416 mL	0.2081 mL	0.4162 mL	2.0812 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Ethyl 3,4,5-trimethoxybenzoateEthyl 3,4,5trimethoxybenzoateEthyl 3,4,5 trimethoxybenzoate

Related Tags: Ethyl 3,4,5-trimethoxybenzoate chemical structure | Ethyl 3,4,5-trimethoxybenzoate in vitro | Ethyl 3,4,5-trimethoxybenzoate formula | Ethyl 3,4,5-trimethoxybenzoate molecular weight