Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN 318463 is 51-fold more selective for PS1.ELN 318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN 318463 is 51-fold more selective for PS1.ELN 318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. |
Targets&IC50 | PS1 γ-secretase:(EC50)12 nM , PS2 γ-secretase: 656 nM |
In vitro | ELN 318463 is a typical wax-secreting enzyme inhibitor and can only replace the active site-directed inhibitor at high concentrations if the substrate is present.Compared with Notch signaling, ELN 318463 is 75-120 times more selective in inhibiting the production of trace iron in cells. |
In vivo | ELN318463 ?leads acute reduction of brain Aβ in in the PDAPP transgene model of Alzheimer's disease (AD) as well as in wild-type FVB strain mice. |
Synonyms | ELN 318463 |
Molecular Weight | 471.8 |
Formula | C19H20BrClN2O3S |
CAS No. | 851600-86-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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ELN318463 851600-86-7 Others ELN-318463 ELN 318463 inhibitor inhibit