EG01377

Name: EG01377
Brand: TargetMol
SKU: T11154
Rating: 4.5 (1 reviews)

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Catalog No. T11154Cas No. 2227996-00-9

EG01377 has antiangiogenic, antimigratory, and antitumor effects.EG01377 is a neuropilin-1 (NRP1) antagonist, with a Kd of 1.32 μM for NRP1-b1, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1, but shows no effect on NRP2.

EG01377

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Catalog No. T11154Cas No. 2227996-00-9

Pack Size	Price	Availability
25 mg	$1,970	1-2 weeks
50 mg	$2,580	1-2 weeks
100 mg	$3,400	1-2 weeks

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Bioactivity

Description	EG01377 has antiangiogenic, antimigratory, and antitumor effects.EG01377 is a neuropilin-1 (NRP1) antagonist, with a Kd of 1.32 μM for NRP1-b1, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1, but shows no effect on NRP2.
Targets&IC50	NRP1-b1:(kd)1.32 μM , NRP1-b1:609 nM , NRP1-a1:609 nM
In vitro	EG01377 inhibits NRP1 in DU145/cells.Ad.NRP1 cells (IC50, 1.6 μM). EG01377 (3, 10, and 30 μM) inhibits VEGF-A stimulated tyrosine phosphorylation of VEGF-R2/KDR. EG01377 (30 μM) also significantly reduces HUVEC cell migration in response to VEGFA, and reduces VEGF-induced angiogenesis. Moreover, EG01377 (30 μM) in combination with VEGFA causes reduction in A375P spheroid outgrowth. EG01377 blocks the production of TGFβ by Nrp1+ Tregs in the presence of tumor cell-derived factors.EG01377 is a neuropilin-1 (NRP1) antagonist, with a Kd of 1.32 μM for NRP1-b1, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1, but shows no effect on NRP2.

Chemical Properties

Molecular Weight	586.68
Formula	C₂₆H₃₀N₆O₆S₂
Cas No.	2227996-00-9
Relative Density.	1.56 g/cm3 (Predicted)

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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