Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 213.00 | |
5 mg | In stock | $ 538.00 | |
10 mg | In stock | $ 778.00 | |
25 mg | In stock | $ 1,180.00 | |
50 mg | In stock | $ 1,620.00 | |
100 mg | In stock | $ 2,180.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 1,780.00 |
Description | Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC). |
In vitro | Delcasertib is composed of a selective δ-protein kinase C (δPKC) inhibitor peptide derived from the δV1-1 portion of δPKC (termed 'cargo peptide”), conjugated reversibly to the cell-penetrating peptide 11-amino acid, arginine-rich sequence of the HIV type 1 transactivator protein (TAT47–57; termed 'carrier peptide”) via a disulfide bond. |
In vivo | KAI-9803 ameliorates pathological conditions in acute myocardial infarction and reduce pain via specific modulation of membrane-translocation of PKC delta or epsilon. Delcasertib has an acceptable safety and tolerability profile when delivered via intracoronary injection during primary percutaneous coronary intervention for ST-segment elevation myocardial infarction.Delcasertib administration at the end of ischemia has been found to reduce cardiac damage caused by ischemia-reperfusion in a rat model of acute myocardial infarction. 14C-KAI-9803 is rapidly delivered to many tissues, including the heart (1.21 μg eq/g tissue), while being quickly cleared from the systemic circulation. The distribution of Delcasertib to tissues such as the liver, kidney, and heart is facilitated by the reversible conjugation to TAT47–57. |
Synonyms | KAI-9803, BMS-875944 |
Molecular Weight | 2880.28 |
Formula | C120H199N45O34S2 |
CAS No. | 949100-39-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 99 mg/mL(34.37 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Delcasertib 949100-39-4 Chromatin/Epigenetic Cytoskeletal Signaling PKC BMS 875944 Inhibitor KAI-9803 KAI 9803 inhibit KAI9803 Protein kinase C BMS-875944 BMS875944 inhibitor