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Dabigatran ethyl ester

Catalog No. T15046 CAS 429658-95-7

Synonyms: Dabigatran (ethyl ester), Dabigatran ethyl ester

Dabigatran ethyl ester (Dabigatran (ethyl ester)) is an emerging oral anticoagulant and it also is a direct inhibitor of thrombin activity.

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Dabigatran ethyl ester Chemical Structure

Dabigatran ethyl ester, CAS 429658-95-7

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2 mg	5 days	$ 34.00

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Purity: 97.63%

Purity: 97.07%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Dabigatran ethyl ester (Dabigatran (ethyl ester)) is an emerging oral anticoagulant and it also is a direct inhibitor of thrombin activity.
In vitro	Dabigatran etexilate was rapidly converted to Dabigatran, with peak plasma dabigatran concentrations being attained after approximately 1.5 h. there is a growing amount of clinical evidence which shows its safety and efficacy. Dabigatran may suppose a revolution in oral anticoagulation. The bioavailability of Dabigatran after p.o. administration of Dabigatran etexilate was 7.2%[1].

Synonyms	Dabigatran (ethyl ester), Dabigatran ethyl ester
Molecular Weight	499.56
Formula	C27H29N7O3
CAS No.	429658-95-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1 mg/mL (2.00 mM), Sonication is recommended.

H2O: 1 mg/mL (2.00 mM), Sonication and heating to 80℃ are recommended.

References and Literature

1. Simon Michaelis, Anett Marais, Anna K. Schrey, et al. Dabigatran and Dabigatran Ethyl Ester: Potent Inhibitors of Ribosyldihydronicotinamide Dehydrogenase (NQO2). J. Med. Chem., 2012, 55 (8):3934-3944 2. Preetpal Singh Sidhu,Aiye Liang, Akul Y. Mehta,et al. Rational Design of Potent, Small, Synthetic Allosteric Inhibitors of Thrombin. J Med Chem. 2011; 54(15): 5522-5531. 3. Santiago Redondo, Maria-Paz Martínez, Marta Ramajo, et al. Pharmacological basis and clinical evidence of dabigatran therapy. J Hematol Oncol. 2011; 4: 53. 4. Stefan Blech, Thomas Ebner, Eva Ludwig-Schwellinger,et al. The Metabolism and Disposition of the Oral Direct Thrombin Inhibitor, Dabigatran, in Humans. DMD ,2008 , 36 (2) 386-399 5. Dabigatran

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Dabigatran ethyl ester 429658-95-7 Proteases/Proteasome Thrombin Dabigatran ethyl ester Dabigatran (ethyl ester) inhibitor inhibit

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