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DMP 777

Catalog No. T15144 CAS 157341-41-8

Synonyms: L-694458

DMP 777 is an orally active inhibitor of human leukocyte elastase.

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DMP 777, CAS 157341-41-8

Pack Size	Availability	Price/USD
2 mg	5 days	$ 95.00
5 mg	5 days	$ 163.00
1 mL * 10 mM (in DMSO)	5 days	$ 227.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

DMP 777 is an orally active inhibitor of human leukocyte elastase.

In vivo

DMP-777-treated animals show marked foveolar hyperplasia in the fundus with the prominent expansion of diastase-resistant, PAS-positive surface mucous cells. DMP-777-treated rats display a marked reduction in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. When DMP-777 is coadministered with omeprazole, there is an obvious decrease in BrdU-positive S-phase cells compared with rats that received DMP-777 alone [1]. After DMP-777(40 mg/kg; p.o.; monkeys) treatment, the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP-777 has occurred in vivo [2]. Mist1-/- mice treated with DMP-777 show fewer chief cells to SPEM transitions and which treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice [3].

Synonyms	L-694458
Molecular Weight	564.67
Formula	C31H40N4O6
CAS No.	157341-41-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 38.33 mg/mL (67.88 mM), Sonication is recommended.

References and Literature

1. Ogawa M, et al. Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777. Dig Dis Sci. 2006 Mar;51(3):431-9. 2. Zagrobelny J, et al. Separation of the four stereoisomers of a potent inhibitor (L-694,458) of human leukocyte elastase and its determination in human plasma using achiral/chiral chromatography with column switching. J Pharm Biomed Anal. 1998 Sep 1;17(6-7 3. Weis VG, et al. Maturity and age influence chief cell ability to transdifferentiate into metaplasia. Am J Physiol Gastrointest Liver Physiol. 2016 Nov 23:ajpgi.00326.2016

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

DMP 777 157341-41-8 Others L694458 L 694458 DMP777 DMP-777 L-694458 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.