Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 327.00 | |
50 mg | In stock | $ 597.00 | |
100 mg | In stock | $ 852.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively. |
Targets&IC50 | GABAA α3 receptor:7.5 nM (ki), GABAA α1 receptor:ki:10 nM , GABAA α5 receptor:2.2 nM (ki), GABAA α2 receptor:13 nM (ki) |
In vivo | DMCM has potent convulsant, proconvulsant and anxiogenic properties in vivo. DMCM (20-60 mg/kg; i.p.) produces modest anxiolytic-like effects in γ2I77 mice[2]. |
Molecular Weight | 350.8 |
Formula | C17H19ClN2O4 |
CAS No. | 1215833-62-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 22.5 mg/mL (64.1 mM), Sonication is recommended.
DMSO: 9 mg/mL (25.7 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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DMCM hydrochloride 1215833-62-7 Membrane transporter/Ion channel Neuroscience GABA Receptor DMCM Hydrochloride inhibitor inhibit