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D-Lin-MC3-DMA

Catalog No. T5823 CAS 1224606-06-7

D-Lin-MC3-DMA, an ionizable cationic Lipid, is a potent siRNA delivery vehicle.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

D-Lin-MC3-DMA, CAS 1224606-06-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 79.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 228.00
50 mg	In stock	$ 349.00
100 mg	In stock	$ 523.00
500 mg	In stock	$ 1,170.00
1 mL * 10 mM (in DMSO)	In stock	$ 113.00

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Purity: 99.95%

Purity: 98.53%

Purity: 98%

Purity: 95%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
In vitro	Replacement of DSPC by unsaturated PCs and DLin-MC3-DMA by the related lipid DLin-KC2-DMA resulted in highly potent transfection reagents for HeLa cells in vitro.
Cell Research	White leghorn chicken embryos at stage 24 (30) were removed and dissected in Hanks buffered saline solution (HBSS).?Forelimbs were pooled and treated for 1 h in dispase to remove epithelial ectoderm.?Limb mesenchyme was dissociated, and resuspended in DMEM with 5% FBS and 1% penicillin/streptomycin.?Cells were plated onto 96-well plates at a density of 2x10^5 or 2x10^7 cells/ml and treated with 0-40 μg/ml LNP-pDNA.?Cultures were incubated overnight at 37℃ and resuspended in PBS buffer for expression analysis using a BD LSRII flow cytometer.?Cell survival was assessed in low-density cultures after 24 h of treatment, by counting the adherent cells remaining after PBS washes.?Viability was determined based on average counts of all adherent cells within a single field of view (100x) normalized to cell counts of untreated cultures.

Molecular Weight	642.1
Formula	C43H79NO2
CAS No.	1224606-06-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

Ethanol: 16.67 mg/mL (25.96 mM)

DMSO: 43.33 mg/mL (67.48 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kulkarni J A , Myhre J L , Chen S , et al. Design of lipid nanoparticles for, in vitro, and, in vivo, delivery of plasmid DNA[J]. Nanomedicine: Nanotechnology, Biology and Medicine, 2017, 13(4):1377-1387.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-COVID-19 Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

D-Lin-MC3-DMA 1224606-06-7 Others Inhibitor D-Lin-MC-3-DMA D Lin MC3 DMA inhibit DLinMC3DMA inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.