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Catalog No. T5823   CAS 1224606-06-7

D-Lin-MC3-DMA, an ionizable cationic Lipid, is a potent siRNA delivery vehicle.

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D-Lin-MC3-DMA Chemical Structure
D-Lin-MC3-DMA, CAS 1224606-06-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 48.00
5 mg In stock $ 79.00
10 mg In stock $ 117.00
25 mg In stock $ 228.00
50 mg In stock $ 349.00
100 mg In stock $ 523.00
500 mg In stock $ 1,170.00
1 mL * 10 mM (in DMSO) In stock $ 113.00
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Purity: 99.95%
Purity: 98.53%
Purity: 98%
Purity: 98%
Purity: 95%
Purity: 98%
Purity: 98%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
In vitro Replacement of DSPC by unsaturated PCs and DLin-MC3-DMA by the related lipid DLin-KC2-DMA resulted in highly potent transfection reagents for HeLa cells in vitro.
Cell Research White leghorn chicken embryos at stage 24 (30) were removed and dissected in Hanks buffered saline solution (HBSS).?Forelimbs were pooled and treated for 1 h in dispase to remove epithelial ectoderm.?Limb mesenchyme was dissociated, and resuspended in DMEM with 5% FBS and 1% penicillin/streptomycin.?Cells were plated onto 96-well plates at a density of 2x10^5 or 2x10^7 cells/ml and treated with 0-40 μg/ml LNP-pDNA.?Cultures were incubated overnight at 37℃ and resuspended in PBS buffer for expression analysis using a BD LSRII flow cytometer.?Cell survival was assessed in low-density cultures after 24 h of treatment, by counting the adherent cells remaining after PBS washes.?Viability was determined based on average counts of all adherent cells within a single field of view (100x) normalized to cell counts of untreated cultures.
Molecular Weight 642.1
Formula C43H79NO2
CAS No. 1224606-06-7


Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

Ethanol: 16.67 mg/mL (25.96 mM)

DMSO: 43.33 mg/mL (67.48 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kulkarni J A , Myhre J L , Chen S , et al. Design of lipid nanoparticles for, in vitro, and, in vivo, delivery of plasmid DNA[J]. Nanomedicine: Nanotechnology, Biology and Medicine, 2017, 13(4):1377-1387.

Related compound libraries

This product is contained In the following compound libraries:
NO PAINS Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-COVID-19 Compound Library

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D-Lin-MC3-DMA 1224606-06-7 Others Inhibitor D-Lin-MC-3-DMA D Lin MC3 DMA inhibit DLinMC3DMA inhibitor