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D-Lin-MC3-DMA

Catalog No. T5823 CAS 1224606-06-7

D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

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D-Lin-MC3-DMA, CAS 1224606-06-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 79.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 228.00
50 mg	In stock	$ 349.00
100 mg	In stock	$ 523.00
500 mg	In stock	$ 1,170.00
1 mL * 10 mM (in DMSO)	In stock	$ 113.00

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Purity: 99.95%

Purity: 98.53%

Purity: 95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
In vitro	Replacement of DSPC by unsaturated PCs and DLin-MC3-DMA by the related lipid DLin-KC2-DMA resulted in highly potent transfection reagents for HeLa cells in vitro.
Cell Research	White leghorn chicken embryos at stage 24 (30) were removed and dissected in Hanks buffered saline solution (HBSS).?Forelimbs were pooled and treated for 1 h in dispase to remove epithelial ectoderm.?Limb mesenchyme was dissociated, and resuspended in DMEM with 5% FBS and 1% penicillin/streptomycin.?Cells were plated onto 96-well plates at a density of 2x10^5 or 2x10^7 cells/ml and treated with 0-40 μg/ml LNP-pDNA.?Cultures were incubated overnight at 37℃ and resuspended in PBS buffer for expression analysis using a BD LSRII flow cytometer.?Cell survival was assessed in low-density cultures after 24 h of treatment, by counting the adherent cells remaining after PBS washes.?Viability was determined based on average counts of all adherent cells within a single field of view (100x) normalized to cell counts of untreated cultures.

Molecular Weight	642.09
Formula	C43H79NO2
CAS No.	1224606-06-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 16.67 mg/mL (25.96 mM)

DMSO: 43.33 mg/mL (67.48 mM)

References and Literature

1. Kulkarni J A , Myhre J L , Chen S , et al. Design of lipid nanoparticles for, in vitro, and, in vivo, delivery of plasmid DNA[J]. Nanomedicine: Nanotechnology, Biology and Medicine, 2017, 13(4):1377-1387.

Citations

1. Morales L C, Rajendran A, Ansari A, et al.Biodistribution of Therapeutic Small Interfering RNAs Delivered with Lipid-Substituted Polyethylenimine-Based Delivery Systems.Molecular Pharmaceutics.2024 2. Marcos-Villar L, Perdiguero B, Anthiya S, et al.Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium.npj Vaccines.2024, 9(1): 53.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Anti-COVID-19 Compound Library Bioactive Compound Library NO PAINS Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

D-Lin-MC3-DMA 1224606-06-7 Others Inhibitor D-Lin-MC-3-DMA D Lin MC3 DMA inhibit DLinMC3DMA inhibitor

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