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Compound 3344

Catalog No. T9184 CAS 2368246-78-8

3344 is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.

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Compound 3344, CAS 2368246-78-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	3344 is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.
In vitro	In vitro competition studies of 3344 binding to KRAS-G12V in waterLOGSY NMR show the anti-RAS scFv inhibits 3344 binding to KRAS. In view of the in vitro inhibition by the anti-RAS scFv of 3344 binding to RASand because the iDAb RAS interferes with BRET signal in cells, 3344 was used for valida?tion of the BRET2 toolbox for RAS-effector PPI inhibitors.

Molecular Weight	390.47
Formula	C24H26N2O3
CAS No.	2368246-78-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Bery et al. eLife 2018;7:e37122.

Related Products

Related compounds with same targets

Divarasib Compound 3344 MC 976 KRAS G12C inhibitor 5 KRas G12C inhibitor 4 KRas G12C inhibitor 2 KRas G12C inhibitor 1 KRAS inhibitor-7

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Keywords

Compound 3344 2368246-78-8 G蛋白偶联受体 MAPK信号通路 Ras Inhibitor inhibitor inhibit

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