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Compound 3344
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Catalog No. T9184Cas No. 2368246-78-8
3344 is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.
Compound 3344
😃Good
Catalog No. T9184Cas No. 2368246-78-8
3344 is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $929 | 1-2 weeks | |
| 50 mg | $1,207 | 1-2 weeks | |
| 100 mg | $1,810 | 1-2 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | 3344 is an inhibitor of KRAS-effector interactions,with an affnity of 126nm. |
| In vitro | In vitro competition studies of 3344 binding to KRAS-G12V in waterLOGSY NMR show the anti-RAS scFv inhibits 3344 binding to KRAS. In view of the in vitro inhibition by the anti-RAS scFv of 3344 binding to RASand because the iDAb RAS interferes with BRET signal in cells, 3344 was used for valida?tion of the BRET2 toolbox for RAS-effector PPI inhibitors. |
| Molecular Weight | 390.47 |
| Formula | C24H26N2O3 |
| Cas No. | 2368246-78-8 |
| Relative Density. | 1.182 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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