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Cimetropium Bromide

Catalog No. T14966 CAS 51598-60-8

Synonyms: DA-3177

Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome.

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Cimetropium Bromide, CAS 51598-60-8

Pack Size	Availability	Price/USD
2 mg	5 days	$ 140.00
25 mg	6-8 weeks	$ 766.00
50 mg	6-8 weeks	$ 996.00
100 mg	6-8 weeks	$ 1,540.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome.
In vitro	Cimetropium reduces the release of labeled acetylcholine (ACh) elicited by electrical field stimulation, particularly when muscarinic autoinhibition is blocked, as observed in superfusion experiments using preparations preloaded with labeled choline [2]. Furthermore, it exhibits a powerful antimuscarinic action by inhibiting the contraction of longitudinal muscle preparations. As a competitive antagonist, Cimetropium Bromide effectively counteracts muscarinic-mediated contractions in isolated colonic preparations from various species, demonstrating affinity values (pA2) between 7.41 and 7.82 [1].
In vivo	Cimetropium Bromide (10-100 μg/kg) counteracts colonic motor response to neostigmine administration (ID50: 27.9 μg/kg); both tonic and phasic components of contractile response are affected. Cimetropium is a potent inhibitor of large bowel motility evoked by both exogenous and endogenous stimuli when administered intravenously to conscious dogs provided with a colonic Thiry fistula. In a comparable range of doses (3-100μg/kg), the drug inhibits motor activity elicited by intraluminal distension [1].

Synonyms	DA-3177
Molecular Weight	438.36
Formula	C21H28BrNO4
CAS No.	51598-60-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (114.06 mM), Sonification is recommended.

References and Literature

1. Identification of orally administered cimetropium bromide in the colon of the rat and its possible local spasmolytic effect. 2. Saitoh N, et al. Characterization of antimuscarinic effect of cimetropium bromide in guinea pig ileum. J Smooth Muscle Res. 1997 Feb;33(1):1-9.

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Keywords

Cimetropium Bromide 51598-60-8 Neuroscience AChR DA 3177 DA3177 DA-3177 inhibitor inhibit

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