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CP-409092

Catalog No. T10869L CAS 194098-25-4

CP-409092 is a partial GABAA receptor agonist. It has anti-anxiety activity.

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CP-409092, CAS 194098-25-4

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Description	CP-409092 is a partial GABAA receptor agonist. It has anti-anxiety activity.
Targets&IC50	GABAA receptor
In vivo	[14C]CP-409,092(P.O.; 100 mg/kg; ) treatment, the total recovery is 89.1%+ or -3.2% for male rats and 89.3%+ or -0.58% for female rats. The pharmacokinetics of CP-409,092 (P.O.; 4 and 15 mg/kg;single intravenous) treatment , are characterized by high clearance of 169+ or -18 mL/min/kg, a volume of distribution of 8.99+ or -1.46 L/kg, and an oral bioavailability of 2.9%+ or -3%.

Molecular Weight	297.35
Formula	C17H19N3O2
CAS No.	194098-25-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 41.67 mg/mL (140.14 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Kamel A, et al. Metabolism, pharmacokinetics and excretion of the GABA(A) receptor partial agonist [(14)C]CP-409,092 in rats. Xenobiotica. 2010 Jun;40(6):400-14.

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