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COH34

COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.

Catalog No. T10859Cas No. 906439-72-3

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Purity:98.21%

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COA HPLC HNMR

COH34

Catalog No. T10859Cas No. 906439-72-3

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$135	In Stock
5 mg	$289	In Stock
10 mg	$455	In Stock
25 mg	$753	In Stock
50 mg	$1,060	In Stock
100 mg	$1,430	In Stock

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Product Introduction

Bioactivity

Description	COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.
Targets&IC50	PARG:0.37 nM
In vitro	COH34 potently inhibits PARP inhibitor-resistant cancer cells[1].
In vivo	COH34 shows antitumor activity in xenograft mouse cancer models[1].
Alias	1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol

Chemical Properties

Molecular Weight	293.38
Formula	C₁₈H₁₅NOS
Cas No.	906439-72-3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 15 mg/mL (51.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4085 mL	17.0427 mL	34.0855 mL	170.4274 mL
5 mM	0.6817 mL	3.4085 mL	6.8171 mL	34.0855 mL
10 mM	0.3409 mL	1.7043 mL	3.4085 mL	17.0427 mL
20 mM	0.1704 mL	0.8521 mL	1.7043 mL	8.5214 mL
50 mM	0.0682 mL	0.3409 mL	0.6817 mL	3.4085 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

COH-34COH 34COH34