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CD38 inhibitor 1

Name: CD38 inhibitor 1
Brand: TargetMol
SKU: T14913
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14913Cas No. 1700637-55-3

CD38 inhibitor 1 is a potent CD38 inhibitor that is effective against human CD38 (IC50 value is 7.3 nM) and mouse CD38 (IC50 value is 1.9 nM).

CD38 inhibitor 1

🥰Excellent

Purity: 99.86%

Catalog No. T14913Cas No. 1700637-55-3

CD38 inhibitor 1 is a potent CD38 inhibitor that is effective against human CD38 (IC50 value is 7.3 nM) and mouse CD38 (IC50 value is 1.9 nM).

Pack Size	Price	Availability
1 mg	$51	In Stock
5 mg	$122	In Stock
10 mg	$213	In Stock
25 mg	$428	In Stock
50 mg	$639	In Stock
100 mg	$890	In Stock
1 mL x 10 mM (in DMSO)	$109	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.86%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	CD38 inhibitor 1 is a potent CD38 inhibitor that is effective against human CD38 (IC50 value is 7.3 nM) and mouse CD38 (IC50 value is 1.9 nM).
Targets&IC50	CD38:7.3 nM(human), CD38:1.9 nM(mouse)
In vivo	METHODS: CD38 inhibitor 1 (compound 78c) was administered intraperitoneally (10 (young mice), 15 (old mice) mg/kg, twice daily) for 4 to 14 weeks, and 78c concentrations in various tissues and plasma were measured. RESULTS Although CD38 inhibitor 1 promoted increases in NAD levels and exercise capacity in old mice, it had no significant effect on NAD levels or exercise tolerance in young (3-month-old) mice. [1]

Chemical Properties

Molecular Weight	413.53
Formula	C₂₂H₂₇N₃O₃S
Cas No.	1700637-55-3
Smiles	COCCO[C@H]1CC[C@@H](CC1)Nc1cc(=O)n(C)c2ccc(cc12)-c1cncs1
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (157.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4182 mL	12.0910 mL	24.1820 mL	120.9102 mL
5 mM	0.4836 mL	2.4182 mL	4.8364 mL	24.1820 mL
10 mM	0.2418 mL	1.2091 mL	2.4182 mL	12.0910 mL
20 mM	0.1209 mL	0.6046 mL	1.2091 mL	6.0455 mL
50 mM	0.0484 mL	0.2418 mL	0.4836 mL	2.4182 mL
100 mM	0.0242 mL	0.1209 mL	0.2418 mL	1.2091 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc