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CCT365623 hydrochloride

Catalog No. T10719 CAS 2126136-98-7

CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses <a href="/target/EGFR" style="display: inline; color: #c13a36">EGFR</a> (pY1068) and <a href="/target/Akt" style="display: inline; color: #c13a36">Akt</a> phosphorylation driven by EGF.

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CCT365623 hydrochloride, CAS 2126136-98-7

Pack Size	Availability	Price/USD
5 mg	10-12 weeks	$ 1,170.00
50 mg	10-12 weeks	$ 2,380.00
100 mg	10-12 weeks	$ 3,100.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF.
Targets&IC50	LOX:0.89 μM
In vitro	CCT365623 inhibits LOX at ~5 μM in the biosensor system. CCT365623 (0-40 μM) concentration-dependently decreases the protein levels of surface EGFR. CCT365623 disrupts HTRA1 multimerization, activates TGFβ1 signaling, suppresses MATN2 expression, suppresses EGFR surface retention, and suppresses EGFR signaling. CCT365623 (5 μM) decreases the protein levels of pY1068 EGFR, pAKT, and MATN2, and increases the protein levels of pSMAD2.
In vivo	CCT365623 (70 mg/kg, oral gavage per day) significantly delays the development of the primary tumors and also suppresses metastatic lung burden in the animals. CCT365623 disrupts EGFR cell surface retention and delays the growth of primary and metastatic tumor cells. CCT365623 exhibits a T1/2PO of 0.6 h and F% (oral bioavailability) of 45%.

Molecular Weight	443.99
Formula	C18H18ClNO4S3
CAS No.	2126136-98-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Tang H, et al. Author Correction: Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface. Nat Commun. 2019 Jul 18;10(1):3151.

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Keywords

CCT365623 hydrochloride 2126136-98-7 Metabolism Lipoxygenase CCT-365623 hydrochloride Inhibitor inhibitor inhibit

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