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CCT365623 hydrochloride
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Catalog No. T10719Cas No. 2126136-98-7
CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor with an IC50 of 0.89 μM and suppresses EGFR (pY1068) and AKT phosphorylation induced by EGF.
CCT365623 hydrochloride
😃Good
Catalog No. T10719Cas No. 2126136-98-7
CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor with an IC50 of 0.89 μM and suppresses EGFR (pY1068) and AKT phosphorylation induced by EGF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,820 | 1-2 weeks | |
| 50 mg | $2,380 | 1-2 weeks | |
| 100 mg | $3,100 | 1-2 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor with an IC50 of 0.89 μM and suppresses EGFR (pY1068) and AKT phosphorylation induced by EGF. |
| Targets&IC50 | LOX:0.89 μM |
| In vitro | CCT365623 inhibits LOX at approximately 5 μM in the biosensor system. CCT365623 (0-40 μM) decreases surface EGFR protein levels in a concentration-dependent manner, disrupts HTRA1 multimerization, activates [TGFβ1] signaling, suppresses MATN2 expression, and reduces EGFR surface retention and signaling. At 5 μM, CCT365623 decreases pY1068 EGFR, pAKT, and MATN2 protein levels, while increasing pSMAD2 protein levels. |
| In vivo | CCT365623 (70 mg/kg, oral gavage per day) significantly delays the development of the primary tumors and also suppresses metastatic lung burden in the animals. CCT365623 disrupts EGFR cell surface retention and delays the growth of primary and metastatic tumor cells. CCT365623 exhibits a T1/2PO of 0.6 h and F% (oral bioavailability) of 45%. |
| Molecular Weight | 443.99 |
| Formula | C18H18ClNO4S3 |
| Cas No. | 2126136-98-7 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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