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Bicyclomycin

Catalog No. T26805 CAS 38129-37-2

Synonyms: Bicozamycin

Bicyclomycin is a broad spectrum antibiotic active against Gram-negative bacteria and the Gram-positive bacterium, Micrococcus luteusn.

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Bicyclomycin, CAS 38129-37-2

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Bicyclomycin is a broad spectrum antibiotic active against Gram-negative bacteria and the Gram-positive bacterium, Micrococcus luteusn.

Synonyms	Bicozamycin
Molecular Weight	302.28
Formula	C12H18N2O7
CAS No.	38129-37-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Tran L, van Baarsel JA, Washburn RS, Gottesman ME, Miller JH. Single-gene deletion mutants of Escherichia coli with altered sensitivity to bicyclomycin, an inhibitor of transcription termination factor Rho. J Bacteriol. 2011 May;193(9):2229-35. doi: 10.1128/JB.01463-10. Epub 2011 Feb 25. PubMed PMID: 21357484; PubMed Central PMCID: PMC3133090. 2. Weber TP, Widger WR, Kohn H. The Mg2+ requirements for rho transcription termination factor: catalysis and bicyclomycin inhibition. Biochemistry. 2002 Oct 15;41(41):12377-83. PubMed PMID: 12369827. 3. Tanaka N, Iseki M, Miyoshi T, Aoki H, Imanaka H. Mechanism of action of bicyclomycin. J Antibiot (Tokyo). 1976 Feb;29(2):155-68. PubMed PMID: 776917. 4. Someya A, Iseki M, Tanaka N. Active groups of bicyclomycin and the reaction with thiols. J Antibiot (Tokyo). 1979 Apr;32(4):402-7. PubMed PMID: 38239.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bicyclomycin 38129-37-2 Bicozamycin inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.