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Benzocaine hydrochloride

Catalog No. T6782 CAS 23239-88-5

Synonyms: Benzocaine HCl, Ethyl p-aminobenzoate hydrochloride, Ethyl 4-aminobenzoate hydrochloride

Benzocaine hydrochloride (Ethyl 4-aminobenzoate hydrochloride) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.

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Benzocaine hydrochloride Chemical Structure

Benzocaine hydrochloride, CAS 23239-88-5

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100 mg	Inquiry	$ 65.00
200 mg	Inquiry	$ 118.00
500 mg	Inquiry	$ 198.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 50.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Benzocaine hydrochloride (Ethyl 4-aminobenzoate hydrochloride) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.

In vitro

AZD7762, a more selective Chk1 inhibitor, inhibits Chk1 phosphorylation of a cdc25C peptide by reversibly binding to the ATP-binding site of Chk1, with IC50 of 5 nM and Ki of 3.6 nM. AZD7762 induces cell arrest with EC50 of 0.620 μM, and significantly abrogates the camptothecin induced G2 arrest with an EC50 of 10 nM, by blocking the chk1 dependent degradation of Cdc25A and activation of Cyclin A. AZD7762 (300 nM) enhances the antitumor efficacy of gemcitabine against SW620 and topotecan against MDA-MB-231 by reducing the GI50 values from 24.1 nM and 2.25 μM to 1.08 nM and 0.15 μM, respectively. [1] AZD7762 shows cytotoxicity against a variety of neuroblastoma cell lines bearing p53 wild type, p53 mutation, Mdm2 amplification or p14 deletion with IC50 values ranging from 82.6-505.9 nM. [2]

Synonyms	Benzocaine HCl, Ethyl p-aminobenzoate hydrochloride, Ethyl 4-aminobenzoate hydrochloride
Molecular Weight	201.65
Formula	C9H11NO2·HCl
CAS No.	23239-88-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 38 mg/mL (188.4 mM)

Ethanol: 38 mg/mL (188.4 mM)

H2O: <1 mg/mL

References and Literature

1. Von Tungeln LS, et al. Food Chem Toxicol. 2011 Oct;49(10):2530-5.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Benzocaine hydrochloride 23239-88-5 Membrane transporter/Ion channel Sodium Channel Ethyl p-aminobenzoate Hydrochloride Ethyl 4-aminobenzoate Hydrochloride Benzocaine HCl Benzocaine Hydrochloride Ethyl p-aminobenzoate hydrochloride Ethyl 4-aminobenzoate hydrochloride inhibitor inhibit

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