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Atosiban

Catalog No. T4996 CAS 90779-69-4

Synonyms: RW22164, RWJ22164

Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.

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Atosiban, CAS 90779-69-4

Pack Size	Availability	Price/USD
5 mg	5 days	$ 62.00
10 mg	5 days	$ 92.00
50 mg	5 days	$ 216.00
100 mg	5 days	$ 315.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	RW22164, RWJ22164
Molecular Weight	994.19
Formula	C45H71N11O14S2
CAS No.	90779-69-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

H2O: 16.67 mg/mL (16.77 mM), Need ultrasonic

DMSO: 16.67 mg/mL (16.77 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Akerlund M, et al. The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin. Acta Obstet Gynecol Scand. 1985;64(6):499-504. 2. Sanu O, et al. Critical appraisal and clinical utility of atosiban in the management of preterm labor. Ther Clin Risk Manag. 2010 Apr 26;6:191-9.

Related compound libraries

This product is contained In the following compound libraries：

FDA-Approved & Pharmacopeia Drug Library

Related Products

Related compounds with same targets

OPC-51803 Argipressin d[Cha4]-AVP acetate(500170-27-4 free base) Conopressin S acetate(111317-90-9 free base) Terlipressin Acetate Felypressin Balovaptan LIXIVAPTAN

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Atosiban 90779-69-4 Endocrinology/Hormones GPCR/G Protein Vasopressin Receptor Oxytocin Receptor RW-22164 nonapeptide RWJ 22164 desamino-oxytocin OXTR vasopressin tocolytic Ca2+ Preterm Inhibitor maternal-fetal inhibit oxytocin RW22164 RWJ22164 RW 22164 RWJ-22164 inhibitor

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