Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 5 days | $ 62.00 | |
10 mg | 5 days | $ 92.00 | |
50 mg | 5 days | $ 216.00 | |
100 mg | 5 days | $ 315.00 |
Description | Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence. |
Synonyms | RW22164, RWJ22164 |
Molecular Weight | 994.19 |
Formula | C45H71N11O14S2 |
CAS No. | 90779-69-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
H2O: 16.67 mg/mL (16.77 mM), Need ultrasonic
DMSO: 16.67 mg/mL (16.77 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Atosiban 90779-69-4 Endocrinology/Hormones GPCR/G Protein Vasopressin Receptor Oxytocin Receptor RW-22164 nonapeptide RWJ 22164 desamino-oxytocin OXTR vasopressin tocolytic Ca2+ Preterm Inhibitor maternal-fetal inhibit oxytocin RW22164 RWJ22164 RW 22164 RWJ-22164 inhibitor