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6α-hydroxy Paclitaxel

Name: 6α-hydroxy Paclitaxel
Brand: TargetMol
SKU: T36896
Rating: 4.5 (1 reviews)

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Catalog No. T36896Cas No. 153212-75-0

Alias 6alpha-hydroxypaclitaxel

6α-hydroxy Paclitaxel (6α-OH-PTX) is a major metabolite of the anticancer compound paclitaxel and is partially cytotoxic.

6α-hydroxy Paclitaxel

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Purity: 99.33%

Catalog No. T36896Alias 6alpha-hydroxypaclitaxelCas No. 153212-75-0

6α-hydroxy Paclitaxel (6α-OH-PTX) is a major metabolite of the anticancer compound paclitaxel and is partially cytotoxic.

Pack Size	Price	USA Warehouse	Global Warehouse
500 μg	$592	35 days	35 days
1 mg	$850	-	In Stock
5 mg	$3,920	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.33%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	6α-hydroxy Paclitaxel (6α-OH-PTX) is a major metabolite of the anticancer compound paclitaxel and is partially cytotoxic.
Targets&IC50	WRL6 cells:213.6 μg/mL, H1299 cells:94.48 μg/mL
Synonyms	6alpha-hydroxypaclitaxel

Chemical Properties

Molecular Weight	869.91
Formula	C₄₇H₅₁NO₁₅
Cas No.	153212-75-0
Smiles	[H][C@]12OC[C@@]1(OC(C)=O)[C@@]1([H])[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C(C)=C([C@@H](OC(C)=O)C(=O)[C@]1(C)[C@@H](O)[C@@H]2O)C3(C)C

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Methanol: 10 mg/mL (11.5 mM), Sonication is recommended.

DMSO: 10 mg/mL (11.5 mM), Sonication is recommended.

Solution Preparation Table

Methanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1495 mL	5.7477 mL	11.4954 mL	57.4772 mL
5 mM	0.2299 mL	1.1495 mL	2.2991 mL	11.4954 mL
10 mM	0.1150 mL	0.5748 mL	1.1495 mL	5.7477 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc